Ministry of Education Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China; Bioinformatics Division, Tsinghua National Laboratory for Information Science and Technology, Beijing 100084, China.
Ministry of Education Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China; Bioinformatics Division, Tsinghua National Laboratory for Information Science and Technology, Beijing 100084, China; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
J Genet Genomics. 2017 May 20;44(5):227-234. doi: 10.1016/j.jgg.2017.04.001. Epub 2017 Apr 29.
Cellular senescence is an irreversible cell cycle arrest program in response to various exogenous and endogenous stimuli like telomere dysfunction and DNA damage. It has been widely accepted as an anti-tumor program and is also found closely related to embryo development, tissue repair, organismal aging and age-related degenerative diseases. In the past decades, numerous efforts have been made to uncover the gene regulatory mechanisms of cellular senescence. There is a strong demand to integrate these data from various resources into one open platform. To facilitate researchers on cellular senescence, we have developed Human Cellular Senescence Gene Database (HCSGD) by integrating multiple online published data sources into a comprehensive senescence gene annotation platform (http://bioinfo.au.tsinghua.edu.cn/member/xwwang/HCSGD). Potential Human Cellular Senescence Genes (HCSGS) were collected by combining information from published literatures, gene expression profiling data and Protein-Protein Interaction networks. Additionally, genes are annotated with gene ontology annotation and microRNA/drug/compound target information. HCSGD provides a valuable resource to visualize cellular senescence gene networks, browse annotated functional information, and retrieve senescence-associated genes with a user-friendly web interface.
细胞衰老（Cellular senescence）是一种针对端粒功能障碍和 DNA 损伤等各种内外源性刺激的不可逆细胞周期停滞程序。它已被广泛认为是一种抗肿瘤程序，也与胚胎发育、组织修复、机体衰老和与年龄相关的退行性疾病密切相关。在过去的几十年中，人们做出了大量努力来揭示细胞衰老的基因调控机制。人们强烈要求将这些来自不同资源的数据整合到一个开放的平台中。为了方便细胞衰老领域的研究人员，我们通过将多个在线发布的数据源整合到一个综合的衰老基因注释平台中，开发了人类细胞衰老基因数据库（HCSGD）（http://bioinfo.au.tsinghua.edu.cn/member/xwwang/HCSGD）。通过结合已发表文献、基因表达谱数据和蛋白质-蛋白质相互作用网络中的信息，收集了潜在的人类细胞衰老基因（HCSGS）。此外，还对基因进行了基因本体注释和 microRNA/药物/化合物靶标信息的注释。HCSGD 提供了一个有价值的资源，用于可视化细胞衰老基因网络、浏览注释的功能信息，并通过用户友好的网络界面检索与衰老相关的基因。
