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肿瘤坏死因子（TNF）与γ干扰素（IFN-γ）抗病毒作用的协同性：TNF诱导的β干扰素起主要作用的证据

Synergy of antiviral actions of TNF and IFN-gamma: evidence for a major role of TNF-induced IFN-beta.

作者信息

Hughes T K, Kaspar T A, Coppenhaver D H

机构信息

Department of Microbiology, University of Texas Medical Branch, Galveston 77550.

出版信息

Antiviral Res. 1988 Nov;10(1-3):1-9. doi: 10.1016/0166-3542(88)90010-1.

DOI:10.1016/0166-3542(88)90010-1
PMID:2852914
Abstract

Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-gamma) directly and through induction of IFN-beta in HEp-2 cells. Antibody to IFN-beta inhibits a large component of the TNF and IFN-gamma synergy and immunoreactive IFN-beta can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-beta is demonstrated.

摘要

肿瘤坏死因子（TNF）可直接增强干扰素-γ（IFN-γ）的抗病毒活性，并通过诱导人喉表皮样癌细胞（HEp-2细胞）产生IFN-β来增强其活性。抗IFN-β抗体可抑制TNF与IFN-γ协同作用的大部分，且在TNF处理的HEp-2细胞的上清液中可检测到免疫反应性IFN-β。此外，还证明了这种协同作用的发展动力学及其对IFN-β抗体抑制的敏感性。

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