Chopra K, Kunchandy J, Kulkarni S K
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Arch Int Pharmacodyn Ther. 1988 Jul-Aug;294:56-63.
Effect of acute administration of a benzodiazepine-inverse agonist, FG-7142, on forced swimming-induced depression was investigated in mice. A single injection of FG-7142 (40 mg/kg) showed a delayed increase in behavioral despair, the peak effect being observed on the 5th and 6th day of FG-7142 administration. beta-Adrenoceptor agonist isoprenaline significantly potentiated FG-7142-induced behavioral despair. FG-7142-induced depression was sensitive to reversal by chronic treatment with propranolol or desipramine. These observations suggest that the inverse agonist FG-7142 upregulates beta-adrenoceptor population leading to behavioral despair in mice.
研究了苯二氮卓反向激动剂FG - 7142急性给药对小鼠强迫游泳诱导的抑郁的影响。单次注射FG - 7142（40毫克/千克）显示行为绝望延迟增加，在给予FG - 7142的第5天和第6天观察到峰值效应。β-肾上腺素能受体激动剂异丙肾上腺素显著增强了FG - 7142诱导的行为绝望。FG - 7142诱导的抑郁对普萘洛尔或地昔帕明的慢性治疗逆转敏感。这些观察结果表明，反向激动剂FG - 7142上调β-肾上腺素能受体数量，导致小鼠出现行为绝望。
