一名患有Y/Y易位男性的姐妹染色单体交换

Sister Chromatid Exchanges in A Male With A Y/Y Translocation.

作者信息

Butler Merlin G

机构信息

Center for Human Genetics, University of Nebraska Medical Center, Omaha, Nebraska 68105.

出版信息

Trans Nebr Acad Sci Affil Soc. 1981;9:9-11.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438199/

Abstract

Sister chromatid exchanges (SCE) are considered indicators of genetic damage and early chromosome changes. The SCE frequency from an infertile 27-year-old, white male with tall stature and a nondicentric Y/Y translocation consisting of one short arm and two long arms of the Y chromosome was determined. The SCE frequency was 7.9 ± SD 1.4 while the SCE frequency from ten control subjects was 8.4 ± SD 0.51. A two-tailed -test was applied to the SCE data and no significant difference was found between the individual with the Y/Y translocation and control subjects. Apparently, this altered chromosome does not interfere with the total chromosome behavior and the number of SCEs produced when compared to ten control subjects of both sexes.

摘要

姐妹染色单体交换（SCE）被视为遗传损伤和早期染色体变化的指标。测定了一名27岁身材高大的不育白人男性的SCE频率，该男性存在由Y染色体的一条短臂和两条长臂组成的非双着丝粒Y/Y易位。其SCE频率为7.9±标准差1.4，而十名对照受试者的SCE频率为8.4±标准差0.51。对SCE数据进行双侧t检验，发现Y/Y易位个体与对照受试者之间无显著差异。显然，与十名男女对照受试者相比，这种改变的染色体并不干扰总染色体行为和产生的SCE数量。

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