Butler M G, Sanger W G, Veonett G E
Mutat Res. 1981 Apr;85(2):71-6. doi: 10.1016/0165-1161(81)90022-4.
The frequency of SCES was significantly increased in the alcoholics analyzed (10.6 &/- SD 0.66) when compared to the frequency of a control group (8.4 &/- SD 0.51). Statistical analysis of the data obtained showed that the increase was not apparently related to age, sex, cigarette smoking, duration in years of alcohol abuse, nutritional status or type of alcoholic beverage commonly consumed by the individual. Alcoholics recovering for at least one year from alcohol abuse were examined and the frequency of SCES was found to be equal to the SCE frequency in the control group. There was no statistical significance between the age, sex of the individual, smoking history and years of abstention from alcohol abuse with respect to the frequency of SCES. Therefore, one year of abstention appears sufficient to allow the SCE frequency to return to that found in the control group. In order to keep extraneous factors at a minimum and to analyze the effect of a particular factor, such as alcohol, on the number of SCES, a careful medical history and screening program was followed. However, more information is needed to determine which factors play a role in causing genetic damage and inducing SCES and to determine the significance SCES may have with respect to genetic information and function.
与对照组（8.4±标准差0.51）相比，所分析的酗酒者中姐妹染色单体互换（SCES）的频率显著增加（10.6±标准差0.66）。对所得数据的统计分析表明，这种增加显然与年龄、性别、吸烟、酗酒年限、营养状况或个体通常饮用的酒精饮料类型无关。对戒酒至少一年的酗酒者进行了检查，发现SCES的频率与对照组的姐妹染色单体互换（SCE）频率相等。就SCES的频率而言，个体的年龄、性别、吸烟史和戒酒年限之间没有统计学意义。因此，戒酒一年似乎足以使SCE频率恢复到对照组的水平。为了将无关因素降至最低并分析特定因素（如酒精）对SCES数量的影响，遵循了详细的病史和筛查程序。然而，需要更多信息来确定哪些因素在导致基因损伤和诱导SCES中起作用，以及确定SCES相对于基因信息和功能可能具有的意义。
