Tan Zihui, Zhang Man, Han Qiang, Wen Jing, Luo Kongjia, Lin Peng, Zhang Lanjun, Yang Hong, Fu Jianhua
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China.
J Cancer. 2017 Apr 8;8(6):1025-1029. doi: 10.7150/jca.16491. eCollection 2017.
Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients. We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers. The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(0.003), sex(0.030), tumor length (=0.043), pT status(<0.001) and pN status(<0.001). Pearson's correlation indicated that the FAR were positively associated with the serum C-reactive protein (CRP) ( =0.583, <0.001), and the NLR ( =0.316, <0.001). Multivariate analysis indicated that age, tumor grade, pT status, pN status and preoperative FAR were independent prognostic factors in patients with ESCC. Preoperative FAR was an independent prognostic factor in ESCC patients. Lower FAR may improve OS of ESCC patients.
凝血和营养在癌症进展中起着重要作用。我们旨在研究纤维蛋白原/白蛋白比值（FAR）对食管鳞状细胞癌（ESCC）患者的影响。我们回顾性分析了2008年1月至2010年12月在本中心接受根治性食管切除术的1135例ESCC患者。使用X-tile软件确定这些生物标志物的最佳临界值。X-tile软件确定的FAR最佳临界值为0.08。FAR与年龄（P = 0.003）、性别（P = 0.030）、肿瘤长度（P = 0.043）、pT分期（P<0.001）和pN分期（P<0.001）在统计学上显著相关。Pearson相关性分析表明，FAR与血清C反应蛋白（CRP）呈正相关（r = 0.583，P<0.001），与中性粒细胞与淋巴细胞比值（NLR）呈正相关（r = 0.316，P<0.001）。多因素分析表明，年龄、肿瘤分级、pT分期、pN分期和术前FAR是ESCC患者的独立预后因素。术前FAR是ESCC患者的独立预后因素。较低的FAR可能改善ESCC患者的总生存期。
