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庆祝抗体研究的一个多世纪:通过复合物形成的否定式肯定。

Celebrating More Than a Century of Research on Antibodies: Affirmation Through Negation via Complex Formation.

作者信息

Greenspan Neil S

机构信息

Case Western Reserve University, Cleveland, Ohio.

出版信息

Pathog Immun. 2017;2(1):60-65. doi: 10.20411/pai.v2i1.198. Epub 2017 Mar 14.

Abstract

In this brief commentary, I highlight the remarkable properties of antibodies (also known as immunoglobulins) revealed by more than 100 years of biomedical research. Since antibodies can be elicited through one or another means against almost any molecule or macromolecule, the universe of antibodies represents a sort of molecular mirror for the totality of molecules that make life possible. Consequently, as recounted below, antibodies play a role in almost every aspect of medicine and biomedical research.

摘要

在这篇简短的评论中,我着重介绍了100多年来生物医学研究揭示的抗体(也称为免疫球蛋白)的非凡特性。由于几乎可以通过任何一种方式针对几乎任何分子或大分子诱导产生抗体,抗体的世界就像是使生命成为可能的所有分子的一种分子镜像。因此,如下所述,抗体在医学和生物医学研究的几乎每个方面都发挥着作用。

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本文引用的文献

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Use of polyclonal/monoclonal antibody therapies in transplantation.多克隆/单克隆抗体疗法在移植中的应用。
Expert Opin Biol Ther. 2017 Mar;17(3):339-352. doi: 10.1080/14712598.2017.1283400. Epub 2017 Jan 30.
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Antibody-mediated organ-allograft rejection.抗体介导的器官移植排斥反应。
Nat Rev Immunol. 2005 Oct;5(10):807-17. doi: 10.1038/nri1702.
8
Interactions of protein antigens with antibodies.蛋白质抗原与抗体的相互作用。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):7-12. doi: 10.1073/pnas.93.1.7.
10

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