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Layer-by-layer assembly of peptide based bioorganic-inorganic hybrid scaffolds and their interactions with osteoblastic MC3T3-E1 cells.基于肽的生物有机-无机杂化支架的逐层组装及其与成骨MC3T3-E1细胞的相互作用。
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Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo.杂合肽与可生物降解明胶水凝胶的组合用于控制释放和增强体内抗肿瘤活性。
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Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research.明胶基纳米粒作为药物和基因传递系统：回顾三十年的研究。
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Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model.口服天然壳聚糖基纳米配方绿茶多酚 EGCG 能有效抑制异种移植模型中的前列腺癌细胞生长。
Carcinogenesis. 2014 Feb;35(2):415-23. doi: 10.1093/carcin/bgt321. Epub 2013 Sep 26.
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Pharmacokinetics and in vivo chemosuppressive activity studies on cryptolepine hydrochloride and cryptolepine hydrochloride-loaded gelatine nanoformulation designed for parenteral administration for the treatment of malaria.盐酸小檗碱及其用于治疗疟疾的经皮给药明胶纳米制剂的药代动力学和体内化疗活性研究。
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A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect.一种新型的明胶交联方法可延缓桑 1-脱氧野尻霉素的释放，从而提供更持久的降血糖效果。
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Poly-(ethylene glycol) modified gelatin nanoparticles for sustained delivery of the anti-inflammatory drug Ibuprofen-Sodium: an in vitro and in vivo analysis.聚乙二醇修饰明胶纳米粒用于抗炎药布洛芬钠的持续释放：体外与体内分析。
Nanomedicine. 2013 Aug;9(6):818-28. doi: 10.1016/j.nano.2013.02.001. Epub 2013 Feb 18.
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Langmuir. 2012 Oct 16;28(41):14553-61. doi: 10.1021/la303062j. Epub 2012 Oct 5.
9
Characterization and scanning electron microscopic investigation of crosslinked freeze dried gelatin matrices for study of drug diffusivity and release kinetics.交联冷冻干燥明胶基质的特性和扫描电子显微镜研究及其药物扩散和释放动力学研究。
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Novel technology for the preparation of self-assembled catechin/gelatin nanoparticles and their characterization.新型自组装儿茶素/明胶纳米粒子的制备技术及其特性研究。
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通过包封于明胶纳米颗粒提高茶多酚的生物利用度和药代动力学。

Improved bioavailability and pharmacokinetics of tea polyphenols by encapsulation into gelatin nanoparticles.

作者信息

Kulandaivelu Karikalan, Mandal Abul Kalam Azad

机构信息

School of Bio Sciences and Technology, VIT University, Vellore - 632014, Tamil Nadu, India.

出版信息

IET Nanobiotechnol. 2017 Jun;11(4):469-476. doi: 10.1049/iet-nbt.2016.0147.

DOI:10.1049/iet-nbt.2016.0147
PMID:28530198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8676446/
Abstract

The authors prepared surface modified (with polyelectrolyte layers), tea polyphenols (TPP) encapsulated, gelatin nanoparticles (TPP-GNP) and characterised them. The size of the spherical nanoparticles was ∼50 nm. Number of polyelectrolyte layers and incubation time influenced the encapsulation efficiency (EE); highest EE was noted in nanoparticles with six polyelectrolyte layers (TPP-GNP-6L) incubated for 4 h. TPP released from TPP-GNP-6L in simulated biological fluids indicated protection and controlled release of TPP due to encapsulation. Mathematical modelling indicated anomalous type as a predominant mode of TPP release. TPP-GNP-6L exhibited enhanced pharmacokinetics in rabbit model compared with free TPP. The area under the concentration-time curve and mean residence time were significantly higher in TPP-GNP-6L compared with free TPP which provide an evidence of higher bioavailability of TPP due to encapsulation. The authors demonstrated that encapsulation of TPP into GNPs favoured slow and sustained release of TPP with improved pharmacokinetics and bioavailability thereby can prolong the action of TPP.

摘要

作者制备了表面改性（带有聚电解质层）、包封有茶多酚（TPP）的明胶纳米颗粒（TPP-GNP）并对其进行了表征。球形纳米颗粒的尺寸约为50纳米。聚电解质层数和孵育时间会影响包封效率（EE）；在孵育4小时的具有六层聚电解质的纳米颗粒（TPP-GNP-6L）中观察到最高的EE。从TPP-GNP-6L在模拟生物流体中释放的TPP表明，由于包封作用，TPP得到了保护并实现了控释。数学模型表明，TPP的释放以非菲克型为主导模式。与游离TPP相比，TPP-GNP-6L在兔模型中表现出增强的药代动力学。与游离TPP相比，TPP-GNP-6L的浓度-时间曲线下面积和平均驻留时间显著更高，这证明了由于包封作用TPP具有更高的生物利用度。作者证明，将TPP包封到明胶纳米颗粒中有利于TPP的缓慢持续释放，改善药代动力学和生物利用度，从而可以延长TPP的作用时间。