Dąbkowski Krzysztof, Łabędź-Masłowska Anna, Zuba-Surma Ewa, Starzyńska Teresa
Department of Gastroenterology. Pomeranian Medical University, Szczecin, Poland.
Department of Cell Biology. Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
Pol Merkur Lekarski. 2017 Apr 21;42(250):137-141.
Various independent studies indicate involvement of different populations of bone marrow-derived stem cells in the process of tissue regeneration. In inflammatory disorders bone marrow stem cells are mobilized into peripherial blood and further to different organs, where they take part in tissue regeneration. Experimental studies have shown that bone marrow stem cells play a pivotal role in regeneration of endo and egzocrine pancreas and have a role in pathogenesis of pancreatitis, diabetes and pancreatic neoplasms. Our review summarize available scientific data about different populations of bone marrow stem cells and their role in pathogenesis of inflammatory disorders with special focus on the role of these cells in pancreatic regeneration and their influence on development of pancreatitis. Presented data show also therapeutic potential of bone marrow stem cells in pancreatitis.
多项独立研究表明，不同群体的骨髓源性干细胞参与了组织再生过程。在炎症性疾病中，骨髓干细胞被动员到外周血中，并进一步迁移到不同器官，在那里它们参与组织再生。实验研究表明，骨髓干细胞在胰腺内分泌和外分泌的再生中起关键作用，并且在胰腺炎、糖尿病和胰腺肿瘤的发病机制中也发挥作用。我们的综述总结了关于不同群体骨髓干细胞的现有科学数据，以及它们在炎症性疾病发病机制中的作用，特别关注这些细胞在胰腺再生中的作用及其对胰腺炎发展的影响。所呈现的数据还显示了骨髓干细胞在胰腺炎中的治疗潜力。
