来自银抗性蛋白SilE的Ag结合位点的模型肽研究。
Model peptide studies of Ag binding sites from the silver resistance protein SilE.
作者信息
Chabert V, Hologne M, Sénèque O, Crochet A, Walker O, Fromm K M
机构信息
Univ. Fribourg, Department of Chemistry, Chemin du Musée 9, 1700 Fribourg, Switzerland.
出版信息
Chem Commun (Camb). 2017 Jun 1;53(45):6105-6108. doi: 10.1039/c7cc02630g.
PMID:28530293
Abstract
Using model peptides, each of the nine MXH or HXM (n = 1, 2) motifs of the silver resistance protein SilE has been shown to coordinate to one Ag ion by its histidine and methionine residues with K in the μM range. This suggests an Ag buffering role for SilE in the case of high Ag overload.
摘要
利用模型肽已表明，抗银蛋白SilE的九个MXH或HXM（n = 1, 2）基序中的每一个都通过其组氨酸和甲硫氨酸残基与一个银离子配位，其平衡常数K在微摩尔范围内。这表明在银严重过载的情况下，SilE具有银缓冲作用。
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