Galynker Igor I, Roane David M, Miner Christian R, Feinberg Todd E, Watts Patricia
Department of Psychiatry, Beth Israel Medical Center, New York, NY.
Am J Geriatr Psychiatry. 1995;3(1):52-59. doi: 10.1097/00019442-199524310-00007. Epub 2012 Aug 8.
This study applies the concept of "negative symptoms," previously used in schizophrenia, to dementia of the Alzheimer type (DAT) and examines the relationship of negative symptoms to cognitive deficits and depression. The negative symptom subscale of the Positive and Negative Symptom Scale (PANSS-N), the Hamilton Depression Scale (Ham-D), and the Mini-Mental State Examination (MMSE) were administered to 26 patients with DAT and to 13 normal control subjects. The mean PANSS-N score in DAT patients was significantly higher than in control subjects. DAT patients demonstrated significant correlation between negative symptoms and cognitive deficits. Ham-D scores did not significantly correlate with MMSE or PANSS-N scores. These results indicate that negative symptoms are prevalent in DAT and do not result from depression.
本研究将先前用于精神分裂症的“阴性症状”概念应用于阿尔茨海默型痴呆（DAT），并探讨阴性症状与认知缺陷及抑郁之间的关系。对26例DAT患者和13名正常对照者进行了阳性和阴性症状量表（PANSS-N）的阴性症状分量表、汉密尔顿抑郁量表（Ham-D）及简易精神状态检查表（MMSE）评估。DAT患者的PANSS-N平均得分显著高于对照者。DAT患者的阴性症状与认知缺陷之间存在显著相关性。Ham-D得分与MMSE或PANSS-N得分无显著相关性。这些结果表明，阴性症状在DAT中普遍存在，并非由抑郁所致。
