McCall W Vaughn, Farah B Andy, Reboussin David, Colenda Christopher C
Department of Psychiatry and Behavioral Medicine, and the Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University.
Am J Geriatr Psychiatry. 1995;3(4):317-324. doi: 10.1097/00019442-199503040-00006. Epub 2012 Sep 27.
The authors compared the efficacy of titrated, moderate-dose and fixed, high-dose strategies for right unilateral (RUL) electroconvulsive therapy (ECT) in a group of elderly patients. Nineteen depressed patients (mean age 76 years) were randomized to receive either fixed, high-dose RUL ECT (n = 10) or titrated, moderate-dose RUL ECT (n = 9). Blind Hamilton Rating Scale for Depression ratings were made before and after each treatment. Patients on the fixed, high-dose regimen responded faster and received fewer treatments (mean = 5.7) than the titrated, moderate-dose group (mean = 8.0). The fixed, high-dose group received greater cumulative stimulus charge but less cumulative EEG seizure time. Final depression ratings and memory self-ratings were similar for the two groups.
作者比较了滴定式中等剂量和固定高剂量策略用于一组老年患者右侧单侧（RUL）电休克治疗（ECT）的疗效。19名抑郁症患者（平均年龄76岁）被随机分为接受固定高剂量RUL ECT（n = 10）或滴定式中等剂量RUL ECT（n = 9）。在每次治疗前后采用盲法进行汉密尔顿抑郁量表评分。与滴定式中等剂量组（平均 = 8.0）相比，固定高剂量方案组患者反应更快，接受的治疗次数更少（平均 = 5.7）。固定高剂量组接受了更大的累积刺激电量，但累积脑电图癫痫发作时间更短。两组的最终抑郁评分和记忆自评相似。
