Loo Colleen K, Katalinic Natalie, Smith Deirdre J, Ingram Anna, Dowling Nathan, Martin Donel, Addison Kerryn, Hadzi-Pavlovic Dusan, Simpson Brett, Schweitzer Isaac
School of Psychiatry, University of New South Wales, Sydney, Australia (Drs Loo and Martin, Ms Katalinic, and Mr Hadzi-Pavlovic); St George Hospital and Wesley Hospital, Sydney, Australia (Dr Loo and Dr Simpson); Black Dog Institute, Sydney, Australia (Drs Loo and Martin, Ms Katalinic, and Mr Hadzi-Pavlovic); and Dr Simpson Department of Psychiatry, University of Melbourne, and The Melbourne Clinic, Melbourne, Australia (Ms Smith and Addison, Mr Dowling, and Dr Schweitzer); Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia (Dr Ingram).
Int J Neuropsychopharmacol. 2014 Dec 5;18(1):pyu045. doi: 10.1093/ijnp/pyu045.
Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy (RUL ECT) is given with an ultrabrief, rather than brief, pulse width.
The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief- pulse RUL ECT, when given at doses which achieve comparable efficacy. One hundred and two participants were assigned to receive ultrabrief (at 8 times seizure threshold) or brief (at 5 times seizure threshold) pulse RUL ECT in a double-blind, randomized controlled trial. Blinded raters assessed mood and cognitive functioning over the ECT course.
Efficacy outcomes were not found to be significantly different. The ultrabrief group showed less cognitive impairment immediately after a single session of ECT, and over the treatment course (autobiographical memory, orientation).
In summary, when ultrabrief RUL ECT was given at a higher dosage than brief RUL ECT (8 versus 5 times seizure threshold), efficacy was comparable while cognitive impairment was less.
一些研究表明，右侧单侧电休克治疗（RUL ECT）采用超短脉冲宽度而非短脉冲宽度时，总体疗效更佳。
本研究的目的是测试在给予能达到相当疗效的剂量时，超短脉冲RUL ECT是否比短脉冲RUL ECT产生更少的认知副作用。在一项双盲随机对照试验中，102名参与者被分配接受超短脉冲（8倍癫痫发作阈值）或短脉冲（5倍癫痫发作阈值）RUL ECT。盲法评估者在ECT疗程中评估情绪和认知功能。
未发现疗效结果有显著差异。超短脉冲组在单次ECT治疗后即刻以及整个治疗过程中（自传体记忆、定向）的认知损害较少。
总之，当超短脉冲RUL ECT给予比短脉冲RUL ECT更高的剂量时（8倍与5倍癫痫发作阈值），疗效相当，但认知损害较少。
