Abu-Sini Mohammad, Mayyas Amal, Al-Karablieh Nehaya, Darwish Rula, Al-Hiari Yusuf, Aburjai Talal, Arabiyat Shereen, Abu-Qatouseh Luay
Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Faculty of Health Sciences, American University of Madaba, Madaba 11821, Jordan.
Molecules. 2017 May 20;22(5):841. doi: 10.3390/molecules22050841.
infection can lead to gastritis, peptic ulcer, and the development of mucosa associated lymphoid tissue (MALT) lymphoma. Treatment and eradication of infection can prevent relapse and accelerate the healing of gastric and duodenal ulcers as well as regression of malignancy. Due to the increasing emergence of antibiotic resistance among clinical isolates of , alternative approaches using newly discovered antimicrobial agents in combination with the standard antibiotic regimens for the treatment of are of major importance. The purpose of the present study was to investigate the effect of newly synthesized 8-amino 7-substituted fluoroquinolone and their correspondent cyclized triazolo derivatives when either alone or combined with metronidazole against metronidazole-resistant . Based on standard antimicrobial susceptibility testing methods and checkerboard titration assay, all of the tested compounds showed interesting antimicrobial activity against 12 clinical strains of , with best in vitro effect for compounds and . Fractional inhibitory concentration (FIC) mean values showed synergistic pattern in all compounds of Group 5. In addition, additive activities of some of the tested compounds of Group 4 were observed when combined with metronidazole. In contrast, the tested compounds showed no significant urease inhibition activity. These results support the potential of new fluoroquinolone derivatives to be useful in combination with anti- drugs in the management of -associated diseases.
感染可导致胃炎、消化性溃疡以及黏膜相关淋巴组织（MALT）淋巴瘤的发生。感染的治疗和根除可预防复发，并加速胃和十二指肠溃疡的愈合以及恶性肿瘤的消退。由于临床分离株中抗生素耐药性的不断出现，使用新发现的抗菌药物与标准抗生素方案联合治疗[感染病原体名称未给出]的替代方法至关重要。本研究的目的是研究新合成的8-氨基-7-取代氟喹诺酮及其相应的环化三唑衍生物单独使用或与甲硝唑联合使用时对甲硝唑耐药的[感染病原体名称未给出]的作用。基于标准抗菌药敏试验方法和棋盘滴定法，所有测试化合物对12株[感染病原体名称未给出]临床菌株均表现出有趣的抗菌活性，其中化合物[具体化合物名称未给出]和[具体化合物名称未给出]的体外效果最佳。部分抑菌浓度（FIC）平均值在第5组的所有化合物中呈协同模式。此外，第4组的一些测试化合物与甲硝唑联合使用时观察到相加活性。相比之下，测试化合物未显示出显著的脲酶抑制活性。这些结果支持了新氟喹诺酮衍生物与抗[感染病原体名称未给出]药物联合用于治疗[感染病原体名称未给出]相关疾病的潜力。
