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石榴皮乙醇提取物的新作用及抗作用

Novel and anti- effects of pomegranate peel ethanol extract.

作者信息

Mayyas Amal, Abu-Sini Mohammad, Amr Rula, Akasheh Rand T, Zalloum Waleed, Khdair Ayman, Hamad Islam, Aburjai Talal, Darwish Rula M, Abu-Qatouseh Luay

机构信息

Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, 11914 Amman, Jordan.

Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, 11821 Madaba, Jordan.

出版信息

Vet World. 2021 Jan;14(1):120-128. doi: 10.14202/vetworld.2021.120-128. Epub 2021 Jan 16.

DOI:10.14202/vetworld.2021.120-128
PMID:33642795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7896906/
Abstract

BACKGROUND AND AIM

Interest in plants with antimicrobial properties has been revived due to emerging problems associated with using antibiotics to eradicate . Accordingly, this study aims to assess the antibacterial effects of and the possible synergistic effect of its extract along with metronidazole against .

MATERIALS AND METHODS

Pomegranate peel ethanol extracts (PPEE) was tested against a control strain of (NCTC 11916) and in female Wistar rats. Moreover, the synergistic effect of PPEE in combination with metronidazole was tested .

RESULTS

The PPEE exhibited a remarkable activity against with a minimum inhibitory concentration (MIC) of 0.156 mg/mL. Furthermore, the extract exhibited a pronounced urease inhibitory activity (IC ~6 mg/mL) against the tested strain. A synergistic effect between PPEE and metronidazole was also observed (fractional inhibitory concentrations <0.5). Oral treatment of rats with PPEE for 8 days produced a significant reduction in gastritis and a significant decrease in both lymphocytic and positive chronicity.

CONCLUSION

Pomegranate extract is probably safe and represents a potential alternative and complementary therapy for reducing associated with gastric ulcers.

摘要

背景与目的

由于使用抗生素根除相关问题的出现，人们对具有抗菌特性的植物的兴趣再度兴起。因此，本研究旨在评估[植物名称]的抗菌作用及其提取物与甲硝唑联合使用对[细菌名称]的可能协同作用。

材料与方法

在雌性Wistar大鼠中，测试石榴皮乙醇提取物（PPEE）对[细菌名称]的对照菌株（NCTC 11916）和[另一种细菌名称]的作用。此外，还测试了PPEE与甲硝唑联合使用的协同作用。

结果

PPEE对[细菌名称]表现出显著活性，最低抑菌浓度（MIC）为0.156 mg/mL。此外，该提取物对受试菌株表现出明显的脲酶抑制活性（IC50约为6 mg/mL）。还观察到PPEE与甲硝唑之间的协同作用（部分抑菌浓度<0.5）。用PPEE对大鼠进行8天的口服治疗，可显著减轻[细菌名称]胃炎，并使淋巴细胞性和阳性慢性炎症均显著减轻。

结论

石榴提取物可能是安全的，代表了一种减少与胃溃疡相关的[细菌名称]的潜在替代和补充疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/c9947987d56c/Vetworld-14-120-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/dcadb0bb3660/Vetworld-14-120-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/7dd11e7d2e89/Vetworld-14-120-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/434d51198376/Vetworld-14-120-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/7743a78c88f2/Vetworld-14-120-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/c9947987d56c/Vetworld-14-120-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/dcadb0bb3660/Vetworld-14-120-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/7dd11e7d2e89/Vetworld-14-120-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/434d51198376/Vetworld-14-120-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/7743a78c88f2/Vetworld-14-120-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e041/7896906/c9947987d56c/Vetworld-14-120-g005.jpg

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