Eckert F, Hein R, Krieg T, Burg G
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1988 Dec;39(12):791-4.
A 57-year-old patient suffered from a cutaneous centroblastic polymorphic non-Hodgkin lymphoma. This tumour first occurred 6 years ago and showed local relapses after two surgical excisions without any internal manifestations. The tumour had unusual morphological features with a sarcomatous growth pattern and numerous multilobated nuclei, which first led to the diagnosis of a malignant fibrous histiocytoma. Additional immunohistological studies of both the primary tumour and the lesions demonstrated the presence of lymphocytic marker proteins and allowed the definitive classifications as a high-grade malignant non-Hodgkin lymphoma of the B-cell type.
一名57岁患者患有皮肤中心母细胞性多形性非霍奇金淋巴瘤。该肿瘤首次出现于6年前，在两次手术切除后出现局部复发，无任何内部表现。肿瘤具有不寻常的形态学特征，呈肉瘤样生长模式，有许多分叶状核，最初诊断为恶性纤维组织细胞瘤。对原发性肿瘤和病变进行的额外免疫组织学研究显示存在淋巴细胞标记蛋白，最终确诊为B细胞型高级别恶性非霍奇金淋巴瘤。
