Pelletier G
MRC Group, Molecular Endocrinology, Laval University Medical Center, Quebec, Canada.
J Androl. 1988 Sep-Oct;9(5):352-5. doi: 10.1002/j.1939-4640.1988.tb01063.x.
Recent data have suggested that atrial natriuretic factors (ANFs) can modulate Leydig cell functions. An in vitro radioautographic procedure on slide-mounted frozen testicular sections was used to localize ANF receptors in rat testis. The radioligand was rat [125I]ANF-28. It was demonstrated that ANF specific binding sites were present only in interstitial cells, and that the other testicular compartments were not significantly labeled. These results suggest that ANF could have some physiologic role in testicular functions.
最近的数据表明，心房利钠因子（ANFs）可以调节睾丸间质细胞的功能。采用体外放射自显影法对冷冻的睾丸切片进行定位，以确定大鼠睾丸中ANF受体的位置。放射性配体为大鼠[125I]ANF-28。结果表明，ANF特异性结合位点仅存在于间质细胞中，而睾丸的其他部分未被显著标记。这些结果提示，ANF在睾丸功能中可能具有某些生理作用。
