Hussain Zahid, Thu Hnin Ei, Amjad Muhammad Wahab, Hussain Fahad, Ahmed Tarek A, Khan Shahzeb
Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia.
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak 56000 Cheras, Kuala Lumpur, Malaysia.
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:1316-1326. doi: 10.1016/j.msec.2017.03.226. Epub 2017 Mar 27.
Curcumin derivatives have been well-documented due to their natural antioxidant, antimicrobial and anti-inflammatory activities. Curcuminoids have also gained widespread recognition due to their wide range of other activities which include anti-infective, anti-mutagenic, anticancer, anti-coagulant, antiarthrititc, and wound healing potential. Despite of having a wide range of activities, the inherent physicochemical characteristics (poor water solubility, low bioavailability, chemical instability, photodegradation, rapid metabolism and short half-life) of curcumin derivatives limit their pharmaceutical significance. Aiming to overcome these pharmaceutical issues and improving therapeutic efficacy of curcuminoids, newer strategies have been attempted in recent years. These advanced techniques include polymeric nanoparticles, nanocomposite hydrogels, nanovesicles, nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, polymeric micelles and polymeric blend films. Incorporation of curcumin in these delivery systems has shown improved solubility, transmembrane permeability, long-term stability, improved bioavailability, longer plasma half-life, target-specific delivery, and upgraded therapeutic efficacy. In this review, a range of in vitro and in vivo studies have been critically discussed to explore the pharmaceutical significance and therapeutic viability of the advanced delivery systems to improve antioxidant, anti-inflammatory and antimicrobial efficacies of curcumin and its derivatives.
姜黄素衍生物因其天然的抗氧化、抗菌和抗炎活性而有充分的文献记载。姜黄素类化合物也因其广泛的其他活性而获得广泛认可，这些活性包括抗感染、抗诱变、抗癌、抗凝血、抗关节炎和伤口愈合潜力。尽管姜黄素衍生物具有广泛的活性，但其固有的物理化学特性（水溶性差、生物利用度低、化学不稳定性、光降解、快速代谢和半衰期短）限制了它们的药学意义。为了克服这些药学问题并提高姜黄素类化合物的治疗效果，近年来人们尝试了新的策略。这些先进技术包括聚合物纳米颗粒、纳米复合水凝胶、纳米囊泡、纳米纤维、纳米杂化支架、纳米缀合物、纳米结构脂质载体（NLCs）、纳米乳液、聚合物胶束和聚合物共混膜。将姜黄素纳入这些递送系统已显示出溶解度提高、跨膜通透性增强、长期稳定性提高、生物利用度改善、血浆半衰期延长、靶向递送以及治疗效果提升。在本综述中，对一系列体外和体内研究进行了批判性讨论，以探讨先进递送系统在提高姜黄素及其衍生物的抗氧化、抗炎和抗菌功效方面的药学意义和治疗可行性。
