Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2020 Aug;34(8):1926-1946. doi: 10.1002/ptr.6658. Epub 2020 Mar 13.
Curcumin has been used in numerous anti-microbial research because of its low side effects and extensive traditional applications. Despite having a wide range of effects, the intrinsic physicochemical characteristics such as low bioavailability, poor water solubility, photodegradation, chemical instability, short half-life and fast metabolism of curcumin derivatives limit their pharmaceutical importance. To overcome these drawbacks and improve the therapeutic ability of curcuminoids, novel approaches have been attempted recently. Nanoparticulate drug delivery systems can increase the efficiency of curcumin in several diseases, especially infectious diseases. These innovative strategies include polymeric nanoparticles, hydrogels, nanoemulsion, nanocomposite, nanofibers, liposome, nanostructured lipid carriers (NLCs), polymeric micelles, quantum dots, polymeric blend films and nanomaterial-based combination of curcumin with other anti-bacterial agents. Integration of curcumin in these delivery systems has displayed to improve their solubility, bioavailability, transmembrane permeability, prolong plasma half-life, long-term stability, target-specific delivery and upgraded the therapeutic effects. In this review paper, a range of in vitro and in vivo studies have been critically discussed to explore the therapeutic viability and pharmaceutical significance of the nano-formulated delivery systems to elevate the anti-bacterial activities of curcumin and its derivatives.
姜黄素由于其副作用低和广泛的传统应用，已被用于许多抗菌研究中。尽管具有广泛的作用，但姜黄素衍生物的固有物理化学特性，如生物利用度低、水溶性差、光降解、化学不稳定性、半衰期短和代谢快，限制了其在药物方面的重要性。为了克服这些缺点并提高姜黄素类药物的治疗能力，最近尝试了新的方法。纳米颗粒药物递送系统可以提高姜黄素在几种疾病中的效率，特别是传染病。这些创新策略包括聚合物纳米粒、水凝胶、纳米乳液、纳米复合材料、纳米纤维、脂质体、纳米结构脂质载体 (NLCs)、聚合物胶束、量子点、聚合物共混膜和基于纳米材料的姜黄素与其他抗菌剂的组合。将姜黄素整合到这些递送系统中已被证明可以提高其溶解度、生物利用度、跨膜通透性、延长血浆半衰期、长期稳定性、靶向递药和提高治疗效果。在这篇综述论文中，对一系列体外和体内研究进行了批判性讨论，以探索纳米配方递送系统的治疗可行性和药物学意义，以提高姜黄素及其衍生物的抗菌活性。
