Zeng Guangjian, Liu Meiying, Jiang Ruming, Heng Chunning, Huang Qiang, Mao Liucheng, Hui Junfeng, Deng Fengjie, Zhang Xiaoyong, Wei Yen
Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, PR China.
Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, PR China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an 710069, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:420-426. doi: 10.1016/j.msec.2017.03.261. Epub 2017 Mar 28.
We reported a simple and efficient method to prepare the hydrophilic luminescent HAp polymer nanocomposites through the combination of ligand exchange and metal free light initiated surface-initiated atom transfer radical polymerization (SI-ATRP) using 10-phenylphenothiazine (PTH) as organic catalyst and 2-methacryloyloxyethyl phosphorylcholine (MPC) and itaconic acid (IA) as monomers. The biological imaging and drug delivery performance of HAp-poly(MPC-IA) nanorods were examined to evaluate their potential for biomedical applications. Results suggested that hydrophilic HAp-poly(MPC-IA) nanorods can be successfully prepared. More importantly, the HAp-poly(MPC-IA) exhibited excellent water dispersibility, desirable biocompatibility and good performance for biological imaging and controlled drug delivery applications. As compared with other controlled living polymerization reactions, the metal free light initiated SI-ATRP displayed many advantages such as easy for handle, mild reaction conditions, toxicity and fluorescence quenching from metal catalysts. Therefore, we believe that this strategy should be a useful and effective strategy for preparation of HAp nanomaterials for biomedical applications.
我们报道了一种简单有效的方法，通过配体交换和无金属光引发的表面引发原子转移自由基聚合（SI-ATRP）相结合，以10-苯基吩噻嗪（PTH）为有机催化剂，2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）和衣康酸（IA）为单体，制备亲水性发光HAp聚合物纳米复合材料。对HAp-聚（MPC-IA）纳米棒的生物成像和药物递送性能进行了研究，以评估其在生物医学应用中的潜力。结果表明，亲水性HAp-聚（MPC-IA）纳米棒能够成功制备。更重要的是，HAp-聚（MPC-IA）表现出优异的水分散性、良好的生物相容性以及在生物成像和可控药物递送应用方面的良好性能。与其他可控活性聚合反应相比，无金属光引发的SI-ATRP具有许多优点，如操作简便、反应条件温和、无金属催化剂的毒性和荧光猝灭等。因此，我们认为该策略对于制备用于生物医学应用的HAp纳米材料应是一种有用且有效的策略。
