Mao Liucheng, Liu Meiying, Huang Long, Xu Dazhuang, Wan Qing, Zeng Guangjian, Dai Yanfeng, Wen Yuanqing, Zhang Xiaoyong, Wei Yen
Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:596-604. doi: 10.1016/j.msec.2017.05.107. Epub 2017 May 17.
Surface modification of mesoporous silica nanoparticles (MSNs) with functional polymers has become one of the most interest topics over the last decade. Among various surface modification strategies, surface-initiated atom transfer radical polymerization (ATRP) has been regarded as one of the most effective methods. However, the typical ATRP strategy is relied on the transition metal ions and their organic ligands as the polymerization catalyst systems. In this work, a novel surface-initiated ATRP method was established for surface functionalization of MSNs using 10-Phenylphenothiazine (PTH) as the catalyst, 2-methacryloyloxyethyl phosphorylcholine (MPC) and itaconic acid (IA) as the monomers. We demonstrated that photo-induced ATRP is very effective for preparation of polymer functionalized MSNs (MSNs-NH-poly(IA-co-MPC)). More importantly, MSNs-NH-poly(IA-co-MPC) displayed well water dispersity, low cytotoxicity, high loading capability and controlled release behavior towards cisplatin. Furthermore, the method based on photo-induced surface-initiated ATRP could effectively overcome the drawbacks of conventional ATRP, which may involve in the residue of transition metal ions, high polymerization temperature, long polymerization term and complex experimental procedure. Therefore, this strategy described above is of great interest for fabrication of multifunctional polymer composites for various applications.
在过去十年中，用功能聚合物对介孔二氧化硅纳米颗粒（MSNs）进行表面改性已成为最受关注的课题之一。在各种表面改性策略中，表面引发的原子转移自由基聚合（ATRP）被认为是最有效的方法之一。然而，典型的ATRP策略依赖于过渡金属离子及其有机配体作为聚合催化剂体系。在这项工作中，建立了一种新型的表面引发ATRP方法，以10-苯基吩噻嗪（PTH）为催化剂，2-甲基丙烯酰氧乙基磷酰胆碱（MPC）和衣康酸（IA）为单体，对MSNs进行表面功能化。我们证明光诱导ATRP对于制备聚合物功能化的MSNs（MSNs-NH-聚（IA-co-MPC））非常有效。更重要的是，MSNs-NH-聚（IA-co-MPC）表现出良好的水分散性、低细胞毒性、高负载能力和顺铂的控释行为。此外，基于光诱导表面引发ATRP的方法可以有效克服传统ATRP可能存在的过渡金属离子残留、聚合温度高、聚合时间长和实验过程复杂等缺点。因此，上述策略对于制备用于各种应用的多功能聚合物复合材料具有重要意义。
