Beiraghdar Fatemeh, Einollahi Behzad, Ghadyani Alireza, Panahi Yunes, Hadjiakhoondi Abbas, Vazirian Mahdi, Salarytabar Ali, Darvishi Behrad
a Nephrology and Urology Research Center , Baghiatallah University of Medical Sciences , Tehran , Iran.
b Department of Pharmacognosy and Medical Plants Research Center Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.
Pharm Biol. 2017 Dec;55(1):1800-1805. doi: 10.1080/13880209.2017.1328445.
As an alternative approach, administration of phytotherapeutic agents in management of benign prostate hyperplasia (BPH), is rapidly growing each day. Different authors have indicated effectiveness of Viola odorata L. (Violaceae), Echium amoenum Fisch. & C.A.Mey. (Boraginaceae) and Physalis alkekengi L. (Solanaceae) in treatment of BPH. However, none have reported the beneficial outcomes of the mixture yet.
This study evaluates the therapeutical effects of V. odorata, E. amoenum and P. alkekengi mixture on symptomatic BPH patients.
Eighty six symptomatic BPH patients with International Prostate Symptom Score (IPSS) of more than 13 and prostate volume of more than 30 cm were randomly allocated to receive a two-week course of placebo (control group) or 1 mL of mixed hydro-alcoholic solution of P. alkekengi, E. amoenum and V. odorata extracts (1.5, 1 and 1.5% respectively) (treatment group).
IPSS score of incomplete urination (42.3 ± 2.04%), frequency of urination (20.08 ± 1.02%), intermittency (40.78 ± 2.16%), urgency (60.91 ± 3.14%), weak stream (50.58 ± 2.14%), straining (55.67 ± 2.53%) and nocturia (40.14 ± 1.89%) in treatment group were significantly decreased after treatment compare to placebo receiving group. Furthermore, the prostate volume (16.92 ± 0.89%) and extant urine volume (28.12 ± 1.36%) also significantly decreased in treatment group compared to control group. No significant side effects or abnormalities in biochemical tests and urinalysis were observed throughout the study.
Based on results, mentioned mixture is safe and effective in improving life quality of patients suffering from BPH.
作为一种替代方法，植物治疗剂在良性前列腺增生（BPH）管理中的应用日益广泛。不同作者已表明香堇菜（堇菜科）、阿米尼亚车叶草（紫草科）和酸浆（茄科）在治疗BPH方面的有效性。然而，尚无关于该混合物有益效果的报道。
本研究评估香堇菜、阿米尼亚车叶草和酸浆混合物对有症状的BPH患者的治疗效果。
86例国际前列腺症状评分（IPSS）超过13且前列腺体积超过30 cm的有症状BPH患者被随机分配接受为期两周的安慰剂疗程（对照组）或1 mL酸浆、阿米尼亚车叶草和香堇菜提取物的混合水醇溶液（分别为1.5%、1%和1.5%）（治疗组）。
与接受安慰剂组相比，治疗组治疗后排尿不完全的IPSS评分（42.3±2.04%）、排尿频率（20.08±1.02%）、间歇性（40.78±2.16%）、尿急（60.91±3.14%）、尿流无力（50.58±2.14%）、排尿费力（55.67±2.53%）和夜尿（40.14±1.89%）均显著降低。此外，与对照组相比，治疗组的前列腺体积（16.92±0.89%）和残余尿量（28.12±1.36%）也显著降低。在整个研究过程中未观察到明显的副作用或生化检查及尿液分析异常。
基于结果，上述混合物在改善BPH患者生活质量方面安全有效。
