Baldini Chiara, Cecchettini Antonella, Gallo Alessia, Bombardieri Stefano
a Department of Clinical and Experimental Medicine , University of Pisa , Pisa , Italy.
b Department of Laboratory Medicine and Advanced Biotechnologies , IRCCS - ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione) , Palermo , Italy.
Expert Rev Proteomics. 2017 Jun;14(6):491-498. doi: 10.1080/14789450.2017.1333904. Epub 2017 May 26.
Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disorder, typically affecting exocrine glands. Recently, a great interest has arisen in searching for novel biomarkers able to improve the diagnostic work-up of the disease as well as the general assessment and the prognostic stratification of pSS patients. From this perspective, salivary proteomics has appeared as a promising tool considering that salivary proteins may closely reflect the underlying disease processes in the salivary glands. Areas covered: Here we will provide an update on the state of the art of proteomics in pSS, focusing in particular on putative novel biomarkers for the disease. There is a special focus on candidate salivary protein and their role in non-invasive diagnosis of pSS. Expert commentary: Proteomics represents an emerging throughput omics-based approach for use in diagnosis of pSS. The studies that have been presented in this review have provided major contributions towards the identification of putative protein biomarkers, that once validated, could be able not only to contribute to a non-invasive diagnosis of pSS but also to the stratification of different disease subsets, ultimately allowing a better comprehension of the disease.
原发性干燥综合征（pSS）是一种复杂的异质性自身免疫性疾病，通常累及外分泌腺。最近，人们对寻找能够改善该疾病诊断检查以及pSS患者总体评估和预后分层的新型生物标志物产生了浓厚兴趣。从这个角度来看，唾液蛋白质组学已成为一种有前景的工具，因为唾液蛋白质可能密切反映唾液腺中的潜在疾病过程。涵盖领域：在此，我们将提供pSS蛋白质组学的最新进展，特别关注该疾病的潜在新型生物标志物。特别关注候选唾液蛋白及其在pSS无创诊断中的作用。专家评论：蛋白质组学是一种新兴的基于高通量组学的方法，用于pSS的诊断。本综述中呈现的研究为鉴定潜在的蛋白质生物标志物做出了重大贡献，一旦得到验证，这些生物标志物不仅有助于pSS的无创诊断，还能对不同疾病亚组进行分层，最终有助于更好地理解该疾病。
