Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Pisa, 56126, Italy.
Biomark Med. 2018 Mar;12(3):275-286. doi: 10.2217/bmm-2017-0297. Epub 2018 Feb 20.
Sjögren's syndrome (pSS) is a complex and heterogeneous disorder characterized by different clinical subsets. Recently, great efforts have been made searching for reliable biomarkers able to ameliorate the diagnostic algorithm and the prognostic stratification of pSS patients and ultimately allowing the scientific community to address some of the unmet needs for the disease. In this review, we have summarized the state of the art of 'traditional' widely acknowledged clinical, serological and histologic biomarkers for pSS with the aim of highlighting their relevance and limitations in clinical practice. We have also explored some of the novel potential biomarkers that have been proposed more recently, potentially able to open new ways in the assessment of the disease.
干燥综合征（pSS）是一种复杂且异质性的疾病，具有不同的临床亚型。最近，人们做出了巨大的努力来寻找可靠的生物标志物，以改善 pSS 患者的诊断算法和预后分层，并最终使科学界能够解决该疾病的一些未满足的需求。在这篇综述中，我们总结了 pSS 的“传统”广泛认可的临床、血清学和组织学生物标志物的最新进展，旨在强调它们在临床实践中的相关性和局限性。我们还探讨了一些最近提出的潜在新型生物标志物，这些标志物可能为疾病的评估开辟新的途径。
