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临床预测指标对髋部骨折患者术前深静脉血栓形成筛查的应用价值

Usefulness of clinical predictors for preoperative screening of deep vein thrombosis in hip fractures.

作者信息

Luksameearunothai Kitchai, Sa-Ngasoongsong Paphon, Kulachote Noratep, Thamyongkit Sorawut, Fuangfa Praman, Chanplakorn Pongsthorn, Woratanarat Patarawan, Suphachatwong Chanyut

机构信息

Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Department of Orthopaedics, Faculty of Medicine Vajira Hospital, Navamindrahiraj University, Bangkok, Thailand.

出版信息

BMC Musculoskelet Disord. 2017 May 22;18(1):208. doi: 10.1186/s12891-017-1582-5.

Abstract

BACKGROUND

Recent studies showed that preoperative deep vein thrombosis (DVT) was common after hip fracture (HF), and preoperative DVT screening has been recommended for preventing the fatal DVT-related complications, especially in elderly HF patients with high surgical risk. However, to our knowledge, no previous studies have demonstrated the correlation between the clinical risk predictors and preoperative DVT. Therefore, this study aimed to correlate those clinical predictors related to DVT risk assessment with the incidence of preoperative DVT.

METHODS

A prospective study was conducted, between July 2015 and June 2016, in 92 HF patients. All patients were evaluated for the DVT-related risk, as patients' characteristics, clinical signs, D-dimer, DVT risk assessment score (Wells score and Caprini score), and then underwent doppler ultrasonography preoperatively. The incidence of preoperative DVT was correlated with each clinical risk predictor, and then significant factors were calculated for diagnostic accuracy.

RESULTS

The average patients' age was 78 ± 10 years. Sixty-eight patients (74%) were female. The incidence of preoperative DVT was 16.3% (n = 15). The median time from injury to doppler ultrasonography was 2 days (range 0-150 days). DVT group showed a significantly higher in Wells score and Caprini score compared to the non-DVT group (p < 0.05 all). Sensitivity and specificity of Wells score ≥ 2 and Caprini score ≥12 were 47 and 81, and 93 and 35%, respectively.

CONCLUSION

DVT risk assessment may be helpful for stratifying the risk of preoperative DVT in elderly HFs. Those with Caprini score ≥ 12 should be screened with doppler ultrasonography preoperatively. Those with Wells score 0-1 had low risk for preoperative DVT, so the surgery could perform without delay.

摘要

背景

近期研究表明,髋部骨折(HF)后术前深静脉血栓形成(DVT)很常见,术前DVT筛查已被推荐用于预防致命的DVT相关并发症,尤其是在手术风险高的老年HF患者中。然而,据我们所知,以前没有研究证明临床风险预测因素与术前DVT之间的相关性。因此,本研究旨在将那些与DVT风险评估相关的临床预测因素与术前DVT的发生率相关联。

方法

2015年7月至2016年6月,对92例HF患者进行了一项前瞻性研究。评估所有患者的DVT相关风险,包括患者特征、临床体征、D-二聚体、DVT风险评估评分(Wells评分和Caprini评分),然后在术前进行多普勒超声检查。术前DVT的发生率与每个临床风险预测因素相关联,然后计算出诊断准确性的显著因素。

结果

患者的平均年龄为78±10岁。68例(74%)为女性。术前DVT的发生率为16.3%(n = 15)。从受伤到进行多普勒超声检查的中位时间为2天(范围0 - 150天)。与非DVT组相比,DVT组的Wells评分和Caprini评分显著更高(所有p < 0.05)。Wells评分≥2和Caprini评分≥12的敏感性和特异性分别为47%和81%,以及93%和35%。

结论

DVT风险评估可能有助于对老年HF患者术前DVT风险进行分层。Caprini评分≥12的患者术前应进行多普勒超声检查。Wells评分为0 - 1的患者术前DVT风险低,因此手术可立即进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8379/5440897/03322f1ba36d/12891_2017_1582_Fig1_HTML.jpg

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