来自多花桃榄（Pouteria ramiflora (Mart.) Radlk.）叶子（山榄科）的三萜类化合物。

Triterpenes from Pouteria ramiflora (Mart.) Radlk. Leaves (Sapotaceae).

作者信息

Rodrigues Patrícia Marques, Dutra Gomes João Victor, Jamal Claudia Masrouah, Cunha Neto Álvaro, Santos Maria Lucilia, Fagg Christopher William, Fonseca-Bazzo Yris Maria, Magalhães Pérola de Oliveira, de Sales Paloma Michelle, Silveira Dâmaris

机构信息

Faculdade de Ciências da Saúde, Universidade de Brasília - UnB, DF, Brazil.

Departamento de Ciências Farmacêuticas - CCS, Universidade Federal do Espírito Santo -UFES, ES, Brazil.

出版信息

Food Chem Toxicol. 2017 Nov;109(Pt 2):1063-1068. doi: 10.1016/j.fct.2017.05.026. Epub 2017 May 19.

DOI:10.1016/j.fct.2017.05.026

PMID:28533130

Abstract

Pouteria ramiflora (Mart.) Radlk. (Sapotaceae) is a species used by inhabitants from the Cerrado for its edible fruits and medicinal value. Hexane crude extracts from leaves and fractions were evaluated for in vitro α-amylase inhibitory activity and antioxidant potential. The fraction with the highest α-amylase inhibitory activity was submitted to a phytochemical study. Three triterpenes were isolated, friedelin, epi-friedelanol, and taraxerol. This is the first report of these compounds isolated from P. ramiflora. Moreover, this is the first report of friedelin isolated from Pouteria sp. Epi-friedelanol was present in significant amounts, suggesting that this compound could be a candidate marker for this species.

摘要

多花桃榄（Pouteria ramiflora (Mart.) Radlk.，山榄科）是一种被塞拉多地区居民用于食用果实和药用价值的物种。对叶的正己烷粗提物及其馏分进行了体外α-淀粉酶抑制活性和抗氧化潜力评估。对具有最高α-淀粉酶抑制活性的馏分进行了植物化学研究。分离出三种三萜类化合物，分别是木栓酮、表木栓醇和蒲公英赛醇。这是首次从多花桃榄中分离出这些化合物的报道。此外，这也是首次从桃榄属植物中分离出木栓酮的报道。表木栓醇含量较高，表明该化合物可能是该物种的候选标记物。