首次从肉鸡源肠炎沙门氏菌中检测到磷霉素耐药基因 。
First Detection of a Fosfomycin Resistance Gene, , in Salmonella enterica Serovar Heidelberg Isolated from Broiler Chickens.
机构信息
Guelph Research and Development Center, Agriculture and Agri-Food Canada, Guelph, Ontario, Canada.
Guelph Research and Development Center, Agriculture and Agri-Food Canada, Guelph, Ontario, Canada
出版信息
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00410-17. Print 2017 Aug.
Abstract
We previously described serovar Heidelberg isolates harboring a chromosomal gene cluster similar to the glutathione -transferase gene, a putative gene conferring resistance to fosfomycin. Here, we show that this new gene, named , confers resistance to fosfomycin. The introduction of into the fosfomycin-susceptible serovar Enteritidis resulted in a substantial increase in the fosfomycin MIC. This finding increases the awareness of antibiotic resistance in Heidelberg from broilers as related to the food safety and public health.
摘要
我们之前曾描述过含有与谷胱甘肽转移酶基因相似的染色体基因簇的海德堡血清型分离株，该基因可能赋予了对磷霉素的抗性。在这里，我们表明这个新基因，命名为，赋予了对磷霉素的抗性。将 导入对磷霉素敏感的肠炎沙门氏菌血清型，导致磷霉素 MIC 值显著增加。这一发现增加了对来自肉鸡的海德堡血清型的抗生素耐药性的认识，与食品安全和公共卫生有关。
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