美国宾夕法尼亚州大肠杆菌中的磷霉素耐药性
Fosfomycin Resistance in Escherichia coli, Pennsylvania, USA.
作者信息
Alrowais Hind, McElheny Christi L, Spychala Caressa N, Sastry Sangeeta, Guo Qinglan, Butt Adeel A, Doi Yohei
出版信息
Emerg Infect Dis. 2015 Nov;21(11):2045-7. doi: 10.3201/eid2111.150750.
Abstract
Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase-producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described.
摘要
在美国，大肠杆菌对磷霉素耐药的情况较为罕见。在美国宾夕法尼亚州鉴定出的一株产超广谱β-内酰胺酶的大肠杆菌临床菌株，表现出由fosA3基因导致的高水平磷霉素耐药。携带该基因的IncFII质粒结构与在中国发现的质粒相似，在中国，磷霉素耐药现象较为常见。
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