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粘细菌代谢物索拉芬A通过减少病毒产生和改变病毒粒子组成来抑制HIV-1。

The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition.

作者信息

Fleta-Soriano Eric, Smutná Katarína, Martínez Javier P, Lorca Oró Cristina, Sadiq S Kashif, Mirambeau Gilles, Lopez-Iglesias Carmen, Bosch Marta, Pol Albert, Brönstrup Mark, Diez Juana, Meyerhans Andreas

机构信息

Infection Biology Group, DCEXS, Universitat Pompeu Fabra, Barcelona, Spain.

Infection Biology Group, DCEXS, Universitat Pompeu Fabra, Barcelona, Spain

出版信息

Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00739-17. Print 2017 Aug.

DOI:10.1128/AAC.00739-17
PMID:28533249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5527598/
Abstract

Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action.

摘要

索拉芬A是一种粘细菌代谢产物，可阻断宿主的乙酰辅酶A羧化酶，此前被鉴定为一种新型HIV抑制剂。在此，我们报告索拉芬A通过减少病毒产生和改变病毒体gp120含量来发挥作用，影响进入能力和感染性。添加棕榈酸可部分逆转这些效应，这表明抑制HIV包膜的棕榈酰化是抗病毒作用的机制之一。

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Homeostatically Maintained Resting Naive CD4 T Cells Resist Latent HIV Reactivation.稳态维持的静息初始CD4 T细胞可抵抗潜伏性HIV的激活。
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J Hepatol. 2015 Oct;63(4):813-21. doi: 10.1016/j.jhep.2015.06.002. Epub 2015 Jun 10.
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