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女性化肾上腺肿瘤继发双侧男性乳房发育症中氟代脱氧葡萄糖摄取增加:1例罕见病例报告及文献复习

Increased F-FDG Uptake in Bilateral Gynecomastia Secondary to Feminizing Adrenal Tumor: A Rare Case Report and Review of Literature.

作者信息

Verma Priyanka, Malhotra Gaurav, Kothari Sneha, Jagtap Rajlaxmi, Asopa Ramesh V

机构信息

Radiation Medicine Centre, Bhabha Atomic Research Centre, TMC Annexe, Jerbai Wadia Road, Parel, Mumbai, India.

Global Hospital, Parel, Mumbai, India.

出版信息

Indian J Nucl Med. 2017 Apr-Jun;32(2):145-147. doi: 10.4103/0972-3919.202246.

DOI:10.4103/0972-3919.202246
PMID:28533648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5439191/
Abstract

A 21 year old male who presented with painful enlargement of both the breasts and a hyperestrogenic state, was found to harbor a heterogeneous mass arising from the right adrenal on contrast enhanced Computed Tomography abdomen. The mass was hypermetabolic with no regional, nodal or distant metastases on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography examination. Notably, substantial tracer uptake was seen in bilateral gynecomastia. The patient underwent a right adrenalectomy with the histopathology report confirming adrenocortical carcinoma. This case demonstrates utility of FDG PET/CT in adrenocortical carcinoma. However, when interpreting FDG PET/CT as a staging tool in oncological male patients, one should consider gynecomastia as a possible cause for increased FDG uptake in the breast as it may lead to a false positive interpretation.

摘要

一名21岁男性,出现双侧乳房疼痛性肿大及雌激素过多状态,腹部增强计算机断层扫描(CT)发现右侧肾上腺有一异质性肿块。氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG PET/CT)检查显示该肿块代谢活跃,无区域、淋巴结或远处转移。值得注意的是,双侧男性乳房发育处可见大量示踪剂摄取。患者接受了右侧肾上腺切除术,组织病理学报告证实为肾上腺皮质癌。本病例显示了FDG PET/CT在肾上腺皮质癌中的应用价值。然而,在将FDG PET/CT作为肿瘤男性患者的分期工具进行解读时,应考虑男性乳房发育可能是乳房FDG摄取增加的原因,因为这可能导致假阳性解读。

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本文引用的文献

1
Spectrum of the Breast Lesions With Increased 18F-FDG Uptake on PET/CT.PET/CT上18F-FDG摄取增加的乳腺病变谱
Clin Nucl Med. 2016 Jul;41(7):543-57. doi: 10.1097/RLU.0000000000001203.
2
FDG PET/CT Scan and Functional Adrenal Tumors: A Pilot Study for Lateralization.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG PET/CT)与功能性肾上腺肿瘤:一项关于定位的初步研究
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Value of 18-F-FDG PET/CT and CT in the Diagnosis of Indeterminate Adrenal Masses.18-F-FDG PET/CT 和 CT 在诊断不确定的肾上腺肿块中的价值。
Int J Endocrinol. 2015;2015:213875. doi: 10.1155/2015/213875. Epub 2015 Feb 2.
4
From the radiologic pathology archives: Adrenal tumors and tumor-like conditions in the adult: radiologic-pathologic correlation.从放射病理学档案中:成人肾上腺肿瘤和肿瘤样病变:放射病理学相关性。
Radiographics. 2014 May-Jun;34(3):805-29. doi: 10.1148/rg.343130127.
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PET and PET/CT imaging in thyroid and adrenal diseases: an update.正电子发射断层扫描(PET)和正电子发射断层扫描/计算机断层扫描(PET/CT)在甲状腺和肾上腺疾病中的应用:更新。
Hormones (Athens). 2013 Jul-Sep;12(3):327-33. doi: 10.1007/BF03401299.
6
Feminizing adrenal tumors: Our experience about three cases.女性化肾上腺肿瘤:我们对三例病例的经验。
Indian J Endocrinol Metab. 2013 May;17(3):509-13. doi: 10.4103/2230-8210.111669.
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