镓-68-PSMA PET/MRI同步检查时多结节性甲状腺肿瘤中的PSMA表达
PSMA Expression in Multinodular Thyroid Neoplasm on Simultaneous Ga-68-PSMA PET/MRI.
作者信息
Jena Amarnath, Zaidi Shuaib, Kashyap Vikas, Jha Abhishek, Taneja Sangeeta
机构信息
Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India.
Department of Surgical Oncology, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India.
出版信息
Indian J Nucl Med. 2017 Apr-Jun;32(2):159-161. doi: 10.4103/0972-3919.202248.
PSMA PET is increasingly being used in imaging of recurrent prostate carcinoma. A case with suspected recurrent Prostate carcinoma (PCa), raised PSA (Prostate specific antigen) and suspected spinal metastases was referred for whole body Ga-68-PSMA PET/MRI. The study revealed PSMA avid recurrent prostate mass and extensive osseous metastases. Abnormal PSMA uptake in the thyroid gland prompted USG-guided FNAC which revealed Hurthle cell neoplasm. Histopathological examination (HPE) of excised gland showed multiple Hurthle cell adenomas in both lobes of thyroid along with foci of papillary thyroid carcinoma which on immunohistochemistry were thyroglobulin positive and PSA negative.
前列腺特异性膜抗原（PSMA）正电子发射断层扫描（PET）越来越多地用于复发性前列腺癌的成像。一名疑似复发性前列腺癌（PCa）、前列腺特异性抗原（PSA）升高且疑似脊柱转移的患者被转诊进行全身镓-68-PSMA PET/磁共振成像（MRI）检查。该研究显示PSMA摄取阳性的复发性前列腺肿块及广泛的骨转移。甲状腺异常的PSMA摄取促使在超声引导下进行细针穿刺抽吸活检（FNAC），结果显示为许特莱细胞肿瘤。对切除腺体的组织病理学检查（HPE）显示甲状腺两叶均有多个许特莱细胞腺瘤以及甲状腺乳头状癌灶，免疫组化显示这些癌灶甲状腺球蛋白阳性而PSA阴性。
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