抑郁症与慢性肝病：是否存在共同的潜在机制？
Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?
作者信息
Huang Xiaoqin, Liu Xiaoyun, Yu Yongqiang
机构信息
Department of Psychiatry, The First Affiliated Hospital of Anhui Medical UniversityHefei, China.
Department of Radiology, The First Affiliated Hospital of Anhui Medical UniversityHefei, China.
出版信息
Front Mol Neurosci. 2017 May 8;10:134. doi: 10.3389/fnmol.2017.00134. eCollection 2017.
Abstract
The occurrence of depression is higher in patients with chronic liver disease (CLD) than that in the general population. The mechanism described in previous studies mainly focused on inflammation and stress, which not only exists in CLD, but also emerges in common chronic diseases, leaving the specific mechanism unknown. This review was to summarize the prevalence and risk factors of depression in CLD including chronic hepatitis B, chronic hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease, and to point out the possible underlying mechanism of this potential link. Clarifying the origins of this common comorbidity (depression and CLD) may provide more information to understand both diseases.
摘要
慢性肝病（CLD）患者中抑郁症的发生率高于普通人群。先前研究中描述的机制主要集中在炎症和应激，这不仅存在于CLD中，也出现在常见的慢性疾病中，具体机制尚不清楚。本综述旨在总结CLD（包括慢性乙型肝炎、慢性肝炎、酒精性肝病和非酒精性脂肪性肝病）中抑郁症的患病率和危险因素，并指出这种潜在联系可能的潜在机制。阐明这种常见共病（抑郁症和CLD）的根源可能为理解这两种疾病提供更多信息。
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