Yang Zhang, Wang Lyu, Xin X U, Jie L I, Shengli H U, Ying Wang
Department of Traditional Chinese Medicine, Cangzh ou Central Hospital, Cangzhou 061001, China.
Thyroid and Breast Surgery Department, Cangzhou Central Hospital, Cangzhou 061001, China.
J Tradit Chin Med. 2025 Jun;45(3):633-638. doi: 10.19852/j.cnki.jtcm.2025.03.016.
To evaluate the therapeutic effect of a self-formulated Traditional Chinese Medicine (TCM), Shugan Jieyu San, on improvement of liver function and depression alleviation in the patients with triple negative breast cancer (TNBC).
A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group (receiving routine tumor treatment and duloxetine) or the treatment group (receiving the TCM in addition to routine treatment).
Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment. However, the treatment group demonstrated significantly better outcomes compared to the control group. Furthermore, the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment, while the treatment group exhibited superior results.
This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression, which was verified by the increase in serum levels of dopamine and serotonin, suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.
评估自拟中药疏肝解郁散对三阴性乳腺癌（TNBC）患者肝功能改善及抑郁缓解的治疗效果。
共纳入60例诊断为TNBC且伴有抑郁的患者，随机分为对照组（接受常规肿瘤治疗及度洛西汀）和治疗组（在常规治疗基础上加用中药）。
治疗后，治疗组和对照组的抑郁症状均减轻，日常生活能力均改善。然而，治疗组的效果明显优于对照组。此外，治疗8周后两组血清多巴胺和血清素水平均升高，但治疗组效果更佳。
该中药在减轻TNBC合并抑郁患者的抑郁症状及改善日常能力方面显示出良好效果，血清多巴胺和血清素水平升高证实了这一点，提示这些神经递质可能参与了该中药的治疗作用。
