Brioni J D, Orsingher O A
Departamento de Farmacologia, Facultad of Ciencias Quimicas Universidad Nacional de Corboda, Argentina.
Physiol Behav. 1988;44(2):193-8. doi: 10.1016/0031-9384(88)90137-0.
Adult female rats perinatally submitted to a protein deprivation schedule and then recovered with balanced chow, were tested under two different operant schedules of reinforcement, variable ratio-20 (VR-20) and differential reinforcement of low rate-5 sec (DRLR-5''). Undernourished animals showed higher response rates in the VR-20 schedule and a lower efficiency in the DRLR-5 as compared to controls, effects that could be attributed to the hyperreactivity to aversive or stressful situations characteristic of these animals. As the behavioral responses to anxiogenic stimuli are sensitive to drugs acting on the GABAergic system, the functionalism of the central GABAergic system in the undernourished group was evaluated by studying the reactivity to the anticonflict effect of diazepam in two conflict tests. Undernourished animals had a lower response to the anticonflict effect of diazepam when compared to control rats. The altered reactivity to the anticonflict effect of diazepam between both groups suggest that some aspects of the GABAergic neurotransmission may be involved in the behavioral abnormalities present in adult rats that were undernourished at perinatal age.
成年雌性大鼠在围产期经历蛋白质剥夺计划，然后用均衡饲料恢复喂养，在两种不同的操作性强化程序下进行测试，即可变比率-20（VR-20）和低比率-5秒差异强化（DRLR-5''）。与对照组相比，营养不良的动物在VR-20程序中表现出更高的反应率，而在DRLR-5中效率较低，这些影响可归因于这些动物对厌恶或应激情况的高反应性。由于对焦虑刺激的行为反应对作用于GABA能系统的药物敏感，通过在两项冲突测试中研究地西泮的抗冲突作用的反应性，评估了营养不良组中枢GABA能系统的功能状态。与对照大鼠相比，营养不良的动物对地西泮的抗冲突作用反应较低。两组之间对地西泮抗冲突作用的反应性改变表明，GABA能神经传递的某些方面可能与围产期营养不良的成年大鼠出现的行为异常有关。
