Laino C H, Cordoba N E, Orsingher O A
Department de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1993 Sep;46(1):89-94. doi: 10.1016/0091-3057(93)90322-k.
Adult rats submitted to a protein deprivation schedule at perinatal age (from 14th day of fetal life until 50 days of age) and then recovered on balanced chow (D rats) were assayed in the elevated plus-maze test for anticonflict effects of diazepam and drugs with therapeutic efficacy in panic disorders as compared with controls (C rats). Diazepam and alprazolam showed a similar anticonflict effect in D rats than in C rats. In contrast, buspirone, which was ineffective in C rats at a wide dosage range, showed a significant anticonflict effect on D rats at 0.3 mg/kg. Neither propranolol, desipramine, nor phenelzine treatment (10 mg/kg/day during 3-7 days) induced anticonflict effect in C rats. Conversely, these treatments fostered a significant and selective anxiolytic effect on D rats. Such results underscore long-lasting alterations caused by early undernutrition, namely, changes in reactivity to the drugs assayed. In addition, perinatally deprived rats may represent a useful animal model for studying potential antipanic agents.
在围产期（从胎儿期第14天到50日龄）接受蛋白质剥夺计划，然后恢复正常饮食（D组大鼠）的成年大鼠，与对照组（C组大鼠）相比，在高架十字迷宫试验中测定了地西泮和对惊恐障碍有治疗效果的药物的抗冲突作用。地西泮和阿普唑仑在D组大鼠中显示出与C组大鼠相似的抗冲突作用。相反，丁螺环酮在C组大鼠的广泛剂量范围内无效，但在D组大鼠中，0.3mg/kg剂量时显示出显著的抗冲突作用。普萘洛尔、地昔帕明或苯乙肼治疗（3-7天内每天10mg/kg）在C组大鼠中均未诱导出抗冲突作用。相反，这些治疗对D组大鼠产生了显著且选择性的抗焦虑作用。这些结果强调了早期营养不良所导致的长期改变，即对所检测药物反应性的变化。此外，围产期营养不良的大鼠可能是研究潜在抗惊恐药物的有用动物模型。
