Brioni J D, Cordoba N, Orsingher O A
Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.
Behav Brain Res. 1989 Aug 1;34(1-2):159-62. doi: 10.1016/s0166-4328(89)80099-3.
Offspring of rats were submitted to a protein deprivation dietary treatment from the third week of gestation until 50 days of age, and later nutritionally rehabilitated for at least 90 days. In the punished lever-pressing conflict test, undernourished animals exhibited a decreased reactivity to the anticonflict effect of a 3 mg/kg dose of diazepam as compared to control animals. This decreased reactivity to diazepam in a shock-induced conflict test indicates that functional alterations in the GABAergic transmission might contribute to the state of hypersensitivity to stressful or aversive situations present in undernourished animals.
将大鼠后代从妊娠第三周开始进行蛋白质剥夺饮食处理，直至50日龄，随后进行至少90天的营养康复。在惩罚性杠杆按压冲突试验中，与对照动物相比，营养不良的动物对3mg/kg剂量地西泮的抗冲突效应反应性降低。在电击诱导的冲突试验中对 地西泮反应性降低表明，γ-氨基丁酸能传递的功能改变可能导致营养不良动物对压力或厌恶情境的超敏状态。
