Faculty of Sciences, University of Shahrekord, Shahrekord, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran.
Biol Trace Elem Res. 2018 Feb;181(2):258-264. doi: 10.1007/s12011-017-1035-x. Epub 2017 May 22.
This research was carried out to evaluate the antidiabetic effects of zinc oxide nanoparticles (ZnO NPs) and thiamine following experimental diabetes. Fifty-six 6-week-old female mice were used and divided into seven groups of eight animals. Diabetes was induced in fasted mice by using intraperitoneal (IP) injection of alloxan (180 mg/kg). Groups included (I) non-diabetic control, (II) thiamine (30 mg/l, IP), (III) alloxan-induced diabetic mice, (IV) diabetes + ZnO NPs (0.1 mg/kg IP), (V) diabetes + ZnO NPs (0.5 mg/kg IP), (VI) diabetes + ZnO NPs (0.1 mg/kg IP) + thiamine (30 mg/l, IP), and (VII) diabetes + ZnO NPs (0.5 mg/kg IP) + thiamine (30 mg/l, IP). Coincident with pancreas recovery, in diabetic treated mice (groups IV to VII), the mean islet volume, islets per square micrometer, and volume density of the pancreas had increased than in alloxan-induced diabetic mice. ZnO NPs and thiamine induced a decreasing blood glucose, lower serum triglyceride (TG), LDL, and total cholesterol (TC) levels in alloxan-induced diabetic mice treated with ZnO NPs and thiamine, simultaneously increasing HDL as well. In conclusion, ZnO NPs and thiamine are potent antidiabetic factors, and that, these compound supplementation possesses hypoglycemic properties and have effect on serum lipid parameters in diabetes mice.
本研究旨在评估氧化锌纳米粒子（ZnO NPs）和硫胺素在实验性糖尿病后的抗糖尿病作用。使用 56 只 6 周龄雌性小鼠，将其分为 7 组，每组 8 只动物。将饥饿的小鼠用腹腔内（IP）注射链脲佐菌素（180mg/kg）诱导糖尿病。各组包括：（I）非糖尿病对照组，（II）硫胺素（30mg/l，IP），（III）链脲佐菌素诱导的糖尿病小鼠，（IV）糖尿病+ZnO NPs（0.1mg/kg IP），（V）糖尿病+ZnO NPs（0.5mg/kg IP），（VI）糖尿病+ZnO NPs（0.1mg/kg IP）+硫胺素（30mg/l，IP），和（VII）糖尿病+ZnO NPs（0.5mg/kg IP）+硫胺素（30mg/l，IP）。与胰腺恢复一致，在糖尿病治疗小鼠（组 IV 至 VII）中，胰岛体积、每平方微米胰岛数和胰腺体积密度均高于链脲佐菌素诱导的糖尿病小鼠。ZnO NPs 和硫胺素可降低血糖、血清三酰甘油（TG）、LDL 和总胆固醇（TC）水平，同时增加 HDL，在接受 ZnO NPs 和硫胺素治疗的糖尿病小鼠中。总之，ZnO NPs 和硫胺素是有效的抗糖尿病因子，这些化合物的补充具有降血糖作用，并对糖尿病小鼠的血清脂质参数有影响。
