Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive 13N240, Bethesda, Maryland 20892, USA.
Nat Rev Urol. 2017 Aug;14(8):455-456. doi: 10.1038/nrurol.2017.75. Epub 2017 May 23.
Despite a rapid increase in the use of anticancer immunotherapy, our understanding of the mechanisms of action and the patients’ responses remains limited. The discovery of immune inhibitory markers in the tumour microenvironment following immunotherapy should improve our understanding and might enable us to better apply combination therapies.
尽管抗癌免疫疗法的应用迅速增加,但我们对其作用机制和患者反应的理解仍然有限。免疫疗法后在肿瘤微环境中发现的免疫抑制标志物应该会增进我们的了解,并可能使我们能够更好地应用联合疗法。