Prokop'eva V D, Laptev B I, Bogomaz S A
Ukr Biokhim Zh (1978). 1988 Nov-Dec;60(6):85-8.
Trifluoperazine, a calmodulin inhibitor, has been studied for its effect on cAMP content in rat heart tissue at various cardiac cycle stages with beta-adrenoreceptors stimulation by izadrine. When trifluoperazine is absent, the cAMP level is found to be decreased at the beginning of the cardiac cycle in comparison with the middle of the cardiac cycle. Trifluoperazine (6 X 10(-6) M) induces an increase of the content of cyclic nucleotides at the beginning of the cardiac cycle and has no effect on its level in the middle of the cardiac cycle. This leads to a decrease of the difference between cAMP concentrations in the defined cardiac cycle regions. The calmodulin-dependent reactions might be expected to play an important role in the regulation of the myocardium cAMP concentration change during the cardiac cycle.
三氟拉嗪是一种钙调蛋白抑制剂，研究了其在伊扎肾上腺素刺激β - 肾上腺素能受体时对大鼠心脏组织在不同心动周期阶段环磷酸腺苷（cAMP）含量的影响。当不存在三氟拉嗪时，发现心动周期开始时的cAMP水平与心动周期中期相比有所降低。三氟拉嗪（6×10⁻⁶ M）可使心动周期开始时环核苷酸含量增加，而对心动周期中期的水平无影响。这导致特定心动周期区域内cAMP浓度差异减小。钙调蛋白依赖性反应可能在心动周期中心肌cAMP浓度变化的调节中起重要作用。
