Boston University School of Public Health , Department of Environmental Health, 715 Albany Street T4W, Boston, Massachusetts 02118, United States.
Division of Analytical & Environmental Toxicology, Department of Laboratory Medicine & Pathology, University of Alberta , Edmonton, Alberta T6G 2R3, Canada.
Environ Sci Technol. 2017 Jul 5;51(13):7667-7675. doi: 10.1021/acs.est.7b00615. Epub 2017 Jun 13.
Human exposure to persistent perfluoroalkyl acids (PFAAs), including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorooctanesulfonate (PFOS), can occur directly from contaminated food, water, air, and dust. However, precursors to PFAAs (PreFAAs), such as dipolyfluoroalkyl phosphates (diPAPs), fluorotelomer alcohols (FTOHs), perfluorooctyl sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs), which can be biotransformed to PFAAs, may also be a source of exposure. PFAAs were analyzed in 50 maternal sera samples collected in 2007-2008 from participants in Vancouver, Canada, while PFAAs and PreFAAs were measured in matching samples of residential bedroom air collected by passive sampler and in sieved vacuum dust (<150 μm). Concentrations of PreFAAs were higher than for PFAAs in air and dust. Positive associations were discovered between airborne 10:2 FTOH and serum PFOA and PFNA and between airborne MeFOSE and serum PFOS. On average, serum PFOS concentrations were 2.3 ng/mL (95%CI: 0.40, 4.3) higher in participants with airborne MeFOSE concentrations in the highest tertile relative to the lowest tertile. Among all PFAAs, only PFNA in air and vacuum dust predicted serum PFNA. Results suggest that airborne PFAA precursors were a source of PFOA, PFNA, and PFOS exposure in this population.
人体接触持久性全氟烷基酸（PFAAs），包括全氟辛酸（PFOA）、全氟壬酸（PFNA）和全氟辛烷磺酸（PFOS），可能直接来自受污染的食物、水、空气和灰尘。然而，PFAAs 的前体（PreFAAs），如双多氟烷基磷酸盐（diPAPs）、氟调聚醇（FTOHs）、全氟辛基磺酰胺（FOSAs）和磺酰胺基乙醇（FOSEs），它们可以生物转化为 PFAAs，也可能是接触的来源。2007-2008 年，在加拿大温哥华的参与者中采集了 50 份母血清样本，分析了其中的 PFAAs，同时还测量了匹配的住宅卧室空气（通过被动采样器收集）和筛分出的真空灰尘（<150μm）中的 PFAAs 和 PreFAAs。空气中和灰尘中的 PreFAAs 浓度高于 PFAAs。发现空气中的 10:2 FTOH 与血清中的 PFOA 和 PFNA 以及空气中的 MeFOSE 与血清中的 PFOS 之间存在正相关关系。与空气中 MeFOSE 浓度最低三分之一相比，最高三分之一的参与者血清 PFOS 浓度平均高出 2.3ng/mL（95%CI：0.40，4.3）。在所有 PFAAs 中，只有空气中和真空灰尘中的 PFNA 可以预测血清 PFNA。结果表明，空气中的 PFAA 前体是该人群中 PFOA、PFNA 和 PFOS 暴露的来源。
