Chernyavskiy Pavel, Edmondson Elijah F, Weil Michael M, Little Mark P
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-9778, USA.
Colorado State University, Fort Collins, CO 80523, USA.
Br J Cancer. 2017 Jun 27;117(1):41-50. doi: 10.1038/bjc.2017.141. Epub 2017 May 23.
Some highly penetrant familial cancer syndromes exhibit elevated leukaemia risk, and there is evidence for familial clustering of lung cancer and other common cancers. Lung cancer and leukaemia are strongly radiogenic, but there are few indications that high-energy beam irradiation is markedly more effective than lower-energy radiation.
We used a Cox model with familially structured random effects to assess 16 mortality end points in a group of 1850 mice in 47 families maintained in a circular-breeding scheme, exposed to accelerated Si or Fe ions (0.4 Gy) or Cs gamma rays (3 Gy).
There is periodicity in the effect of familial relatedness, which is most pronounced for pulmonary adenoma, Harderian-gland adenoma, Harderian-gland tumour, ectodermal tumour, pulmonary adenocarcinoma and hepatocellular carcinoma (P=0.0001/0.0003/0.0017/0.0035/0.0257/0.0340, respectively) with families that are 3-4 generations apart most strongly correlated; myeloid leukaemia also exhibited a striking periodic correlation structure. The relative risks of high-energy Si or Fe ions are not significantly different and are less than for Cs gamma-rays for most end points at the doses used.
There is periodicity in the effect of familial relatedness for various cancer sites. The effects per unit dose of high-energy charged particle beams are no higher than ninefold those of lower-energy gamma radiation.
一些高外显率的家族性癌症综合征显示白血病风险升高，并且有证据表明肺癌和其他常见癌症存在家族聚集性。肺癌和白血病具有很强的辐射致发性，但几乎没有迹象表明高能束照射明显比低能辐射更有效。
我们使用具有家族结构随机效应的Cox模型，对采用循环育种方案饲养的47个家族中的1850只小鼠进行评估，使其暴露于加速的硅或铁离子（0.4 Gy）或铯γ射线（3 Gy）下，观察16个死亡终点。
家族相关性效应存在周期性，这在肺腺瘤、哈氏腺腺瘤、哈氏腺肿瘤、外胚层肿瘤、肺腺癌和肝细胞癌中最为明显（P值分别为0.0001/0.0003/0.0017/0.0035/0.0257/0.0340），相隔3 - 4代的家族相关性最强；髓系白血病也表现出显著的周期性相关结构。在所使用的剂量下，对于大多数终点而言，高能硅或铁离子的相对风险没有显著差异，且低于铯γ射线。
家族相关性效应在不同癌症部位存在周期性。高能带电粒子束每单位剂量的效应不高于低能γ辐射的九倍。
