Folsom Aaron R
Am J Epidemiol. 2017 Jun 1;185(11):1000-1001. doi: 10.1093/aje/kwx073.
Kuller and Reisler's 1971 publication (Am J Epidemiol. 1971;93(1):1-9) was an important contribution to the understanding of the epidemiology of cardiovascular diseases, particularly stroke. The authors synthesized pathological and risk-factor evidence to theorize why rates of various subtypes of arterial disease might vary across populations. Specifically, they suggested that different population levels of blood pressure, lipids, and glucose led to population differences in the location and extent of arterial disease. The publication is an excellent model of how to integrate data on person, place, and time of a major public health problem, together with information on pathology and factors that determine individual risk, to derive a coherent explanation for population patterns in cardiovascular disease. The authors' basic theory has proven solid for the past 5 decades.
库勒和赖斯勒1971年发表的论文（《美国流行病学杂志》。1971年；93(1):1 - 9）对理解心血管疾病，尤其是中风的流行病学做出了重要贡献。作者综合了病理学和风险因素证据，以推测为何不同人群中各种动脉疾病亚型的发病率可能存在差异。具体而言，他们认为不同人群的血压、血脂和血糖水平导致了动脉疾病在位置和范围上的人群差异。该出版物是一个很好的范例，展示了如何整合关于一个重大公共卫生问题的人、地点和时间的数据，以及关于病理学和决定个体风险的因素的信息，从而对心血管疾病的人群模式得出连贯的解释。在过去的50年里，作者的基本理论已被证明是可靠的。
