Kim Haein, Jeong Yong Taek, Choi Min Sung, Choi Jaekyun, Moon Seok Jun, Kwon Jae Young
Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.
Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea.
Mol Cells. 2017 May 31;40(5):331-338. doi: 10.14348/molcells.2017.0028. Epub 2017 May 2.
Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner.
进食调节对动物生存至关重要。咽感觉器官可作为食物质量的第二道检查点，这是由于它们位于外部味觉器官（如最初评估食物质量的唇叶）和消化道之间。越来越多的证据支持咽感觉神经元调节进食，但仍有许多未知之处。我们发现，在LSO（一种表达四种味觉受体的成年咽器官）中的一对味觉受体神经元参与了对高浓度钠离子的进食抑制反应。RNA干扰实验和突变分析表明，味觉受体对这一过程是必需的。这种由食物来源是否被视为开胃所决定的进食偏好会受到营养状况的影响，即当动物饥饿时，对能量的需求超过了食物来源的吸引力。我们的结果提供了实验证据，表明参与进食的因素以依赖于背景的方式发挥作用。
