de Oliveira Daniela Leite, Hirotsu Camila, Tufik Sergio, Andersen Monica Levy
Department of PsychobiologyUniversidade Federal de São Paulo, São Paulo, Brazil.
Department of PsychobiologyUniversidade Federal de São Paulo, São Paulo, Brazil
J Endocrinol. 2017 Jul;234(1):R23-R36. doi: 10.1530/JOE-16-0514. Epub 2017 May 23.
The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin D. Poor sleep efficiency and sleep disorders have been shown to have an important role in hyperalgesia, and be associated with different vitamin D values. Vitamin D has been inversely correlated with painful manifestations, such as fibromyalgia and rheumatic diseases. Studies have demonstrated a possible action of vitamin D in the regulatory mechanisms of both sleep and pain. The supplementation of vitamin D associated with good sleep hygiene may have a therapeutic role, not only in sleep disorders but also in the prevention and treatment of chronic pain conditions.
维生素D在骨矿物质代谢中的作用众所周知。多项研究表明其对不同生物学机制有作用，如伤害性感受敏感性和睡眠-觉醒周期调节。睡眠是一个由中枢神经系统不同区域（主要是下丘脑）与多种神经递质共同调节的重要生物学过程。疼痛可分为伤害性疼痛、神经性疼痛和心理性疼痛，受中枢神经系统和外周神经系统共同调节。在外周神经系统中，免疫系统参与导致痛觉过敏的炎症过程。睡眠剥夺是与痛觉过敏相关的一种重要情况，最近它也与维生素D有关。睡眠效率低下和睡眠障碍已被证明在痛觉过敏中起重要作用，并与不同的维生素D值相关。维生素D与纤维肌痛和风湿性疾病等疼痛表现呈负相关。研究表明维生素D在睡眠和疼痛的调节机制中可能发挥作用。补充维生素D并结合良好的睡眠卫生习惯可能具有治疗作用，不仅对睡眠障碍有效，而且对慢性疼痛状况的预防和治疗也有效。
