Azevedo Daniela, Rios Elisabete, Vendeira Lurdes, Sarmento Cristina
Clinical Oncology Department, Centro Hospitalar de São João, Porto - Portugal.
Anatomic Pathology Department, Centro Hospitalar de São João, Porto - Portugal.
Autops Case Rep. 2017 Mar 30;7(1):31-35. doi: 10.4322/acr.2017.002. eCollection 2017 Jan-Mar.
Small cell neuroendocrine carcinoma rarely appears primarily in the head and neck and exhibits aggressive behavior with a poor prognosis. The pathologist has a significant role in the diagnosis, and a consensual treatment still does not exist. The authors report the case of a middle-aged male patient who presented repeated episodes of massive epistaxis. The diagnostic work-up disclosed the diagnosis of small cell neuroendocrine carcinoma of the nasopharynx. The patient was treated with chemotherapy followed by radiotherapy. Imaging examinations performed after the end of treatment showed apparent complete remission of the disease. The patient was kept under active surveillance with no signs of local relapse or distant metastasis after 4 years of follow-up.
小细胞神经内分泌癌很少原发于头颈部，具有侵袭性，预后较差。病理学家在诊断中起着重要作用，目前尚无共识性的治疗方法。作者报告了一例中年男性患者，该患者反复出现大量鼻出血。诊断性检查确诊为鼻咽小细胞神经内分泌癌。患者接受了化疗，随后进行了放疗。治疗结束后进行的影像学检查显示疾病明显完全缓解。随访4年后，患者接受积极监测，未出现局部复发或远处转移迹象。
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