替代健康饮食指数与寻常型天疱疮严重程度的相关性：一项横断面研究。
Association of alternative healthy eating index and severity of pemphigus vulgaris: A cross-sectional study.
机构信息
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
PLoS One. 2023 Dec 11;18(12):e0295026. doi: 10.1371/journal.pone.0295026. eCollection 2023.
BACKGROUND
Evidence on the association between following healthy eating and the severity of pemphigus vulgaris (PV) is scarce. Therefore, the aim of this cross-sectional study aimed to investigate the relationship between adherence to the alternative healthy eating index (AHEI) and the severity of Pemphigus vulgaris disease in adults.
METHODS
In this hospital-based cross-sectional study, a total of 138 pemphigus vulgaris cases were studied, of which 108 had pemphigus disease area index (PDAI) ≤15, and 30 had PDAI>15. Dietary intakes were assessed using a valid 168-item food frequency questionnaire (FFQ). To calculate the AHEI, the data received from the diet were used. The subjects of this index received a score of 1-10. The final AHEI was calculated by summing the component scores.
RESULTS
After adjusting for age and sex, we found that individuals with the highest AHEI score were 72% less likely to have increased PV severity compared with those with the lowest score (OR: 0.28; 95% CI: 0.08-0.92, P trend = 0.020). Further control for another potential confounder, intake energy, made the association stronger (OR: 0.24; 95% CI: 0.06-0.88, P trend = 0.017). Also, after controlling the body mass index (BMI) confounding factor, it maintained its strong relationship (OR: 0.24; 95% CI: 0.06-0.88, P trend = 0.016).
CONCLUSION
The evidence of our study shows that following the healthy eating index is associated with a reduction in the severity of pemphigus vulgaris. Prospective cohort studies are needed to confirm these findings.
背景
关于遵循健康饮食与寻常型天疱疮（PV）严重程度之间关联的证据很少。因此，本横断面研究旨在调查成人中坚持替代健康饮食指数（AHEI）与寻常型天疱疮疾病严重程度之间的关系。
方法
在这项基于医院的横断面研究中，共研究了 138 例寻常型天疱疮病例，其中 108 例天疱疮疾病面积指数（PDAI）≤15，30 例 PDAI>15。采用有效的 168 项食物频率问卷（FFQ）评估饮食摄入。为了计算 AHEI，使用从饮食中获得的数据。该指数的受试者得分为 1-10。通过将各成分得分相加来计算最终的 AHEI。
结果
在校正年龄和性别后，我们发现，与得分最低者相比，得分最高者发生 PV 严重程度增加的可能性低 72%（OR：0.28；95%CI：0.08-0.92，P 趋势=0.020）。进一步控制另一个潜在混杂因素，即摄入能量，使关联更强（OR：0.24；95%CI：0.06-0.88，P 趋势=0.017）。此外，在控制体重指数（BMI）混杂因素后，其仍保持较强的相关性（OR：0.24；95%CI：0.06-0.88，P 趋势=0.016）。
结论
本研究证据表明，遵循健康饮食指数与寻常型天疱疮严重程度降低相关。需要前瞻性队列研究来证实这些发现。
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