Department of Chemistry and Nano Science (BK 21 Plus), Ewha Womans University, 03760 Seoul, Korea.
Chem Soc Rev. 2017 Jul 17;46(14):4299-4328. doi: 10.1039/c7cs00064b.
Recent advances in transition metal-catalyzed C-H bond functionalization have profoundly impacted synthetic strategy. Since organic substrates typically contain several chemically distinct C-H bonds, controlling the regioselectivity of C-H bond functionalization is imperative to harness its full potential. Moreover, the ability to alter reaction pathways to selectively functionalize different C-H bonds in a substrate represents a greater opportunity and challenge. The choice of catalysts, ligands, solvents, and even more subtle variations of the reaction conditions have been shown to allow the formation of regioisomeric C-H functionalization products starting from the same precursors. This review describes recent advances in transition metal-catalyzed divergent C-H bond functionalization that highlight its potential in organic synthesis.
近年来，过渡金属催化的 C-H 键功能化在合成策略上取得了重大进展。由于有机底物通常含有几种化学性质不同的 C-H 键，因此控制 C-H 键功能化的区域选择性对于充分发挥其潜力至关重要。此外，改变反应途径以选择性地官能化底物中不同的 C-H 键的能力代表了更大的机会和挑战。已经证明，催化剂、配体、溶剂的选择，甚至反应条件的更细微变化，都可以从相同的前体开始形成区域异构体 C-H 官能化产物。本综述描述了过渡金属催化的发散 C-H 键功能化的最新进展，突出了其在有机合成中的潜力。
