Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Eur Rev Med Pharmacol Sci. 2017 May;21(9):2192-2198.
To analyze the effect of S100β protein on postoperative cognitive dysfunction (POCD) in patients who underwent single valve replacement surgery.
Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were applied to evaluate 178 patients who underwent single valve replacement surgery under general anesthesia from June 2014 to December 2015. Patients were assessed 1 day before surgery and on postoperative days 2 and 9. Thirty-two patients were identified as having postoperative cognitive dysfunction (the POCD group), while 146 cases did not experience POCD (the control group). A total of 155 healthy adult volunteers from the Medical Center were simultaneously chosen (healthy comparison group). Serum S100β levels from the three groups of patients were measured by ELISA.
In the POCD group, serum S100β levels were significantly higher than those of the control group and healthy comparison group (p < 0.05). The postoperative length of stay in the hospital for patients in the POCD group was significantly increased (p < 0.05).
The expression of serum S100β in patients with POCD was significantly increased. S100β may represent a potential target for the diagnosis and treatment of cognitive dysfunction after cardiac surgery under general anesthesia.
分析 S100β 蛋白对行单瓣膜置换术患者术后认知功能障碍（POCD）的影响。
采用简易精神状态检查量表（MMSE）和蒙特利尔认知评估量表（MoCA）对 2014 年 6 月至 2015 年 12 月期间 178 例行全身麻醉下单瓣膜置换术的患者进行评估，于术前 1 天和术后第 2、9 天进行评估。32 例患者被诊断为术后认知功能障碍（POCD 组），146 例患者未发生 POCD（对照组）。同期选择 155 例来自医疗中心的健康成年志愿者作为健康对照组。采用 ELISA 法检测三组患者的血清 S100β 水平。
POCD 组患者的血清 S100β 水平明显高于对照组和健康对照组（p＜0.05）。POCD 组患者的术后住院时间明显延长（p＜0.05）。
POCD 患者血清 S100β 表达明显升高。S100β 可能成为全麻下心脏手术后认知功能障碍诊断和治疗的潜在靶点。
