Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.
Mult Scler. 2017 Oct;23(11):1442-1452. doi: 10.1177/1352458517709362. Epub 2017 May 24.
Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process. Here, we describe six promising neurodegenerative biomarkers in MS (neurofilament proteins, neurofilament antibodies, tau, N-acetylaspartate, chitinase and chitinase-like proteins and osteopontin), critically evaluating the evidence using a modified Bradford Hill criteria.
神经退行性变在多发性硬化症（MS）中起着关键作用，导致患者长期残疾。然而，由于疾病机制复杂，预后是不可预测的，只有使用特定于潜在过程病理生物学的生物标志物才能清楚地了解这些机制。在这里，我们描述了 MS 中六种有前途的神经退行性生物标志物（神经丝蛋白、神经丝抗体、tau、N-乙酰天冬氨酸、几丁质酶和几丁质酶样蛋白以及骨桥蛋白），并使用改良的布拉德福德·希尔标准对证据进行了严格评估。
