狼疮动物模型的最新进展。
An update on lupus animal models.
作者信息
Li Wei, Titov Anton A, Morel Laurence
机构信息
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
出版信息
Curr Opin Rheumatol. 2017 Sep;29(5):434-441. doi: 10.1097/BOR.0000000000000412.
PURPOSE OF REVIEW
The complexity and heterogeneity of the clinical presentation in systemic lupus of erythematosus (SLE), combined to the inherent limitations of clinical research, have made it difficult to investigate the cause of this disease directly in patients. Various mouse models have been developed to dissect the cellular and genetic mechanisms of SLE, as well as to identify therapeutic targets and to screen treatments. The purpose of this review is to summarize the major spontaneous and induced mouse models of SLE and to provide an update on the major advances they have contributed to the field.
RECENT FINDINGS
Mouse models of SLE have continued to contribute to understand the cellular, signaling and metabolic mechanisms contributing to the disease and how targeting these pathways can provide therapeutic targets. Whenever possible, we discuss the advantage of using one model over the others to test a specific hypothesis.
SUMMARY
Spontaneous and induced models of lupus models are useful tools for the study of the cause of the disease, identify therapeutic targets and screen treatments in preclinical studies. Each model shares specific subsets of attributes with the disease observed in humans, which provides investigators a tool to tailor to their specific needs.
综述目的
系统性红斑狼疮（SLE）临床表现的复杂性和异质性，再加上临床研究固有的局限性，使得直接在患者中研究该疾病的病因变得困难。已开发出各种小鼠模型来剖析SLE的细胞和遗传机制，以及确定治疗靶点并筛选治疗方法。本综述的目的是总结SLE的主要自发性和诱导性小鼠模型，并提供它们在该领域所取得主要进展的最新情况。
最新发现
SLE小鼠模型继续有助于理解导致该疾病的细胞、信号传导和代谢机制，以及针对这些途径如何提供治疗靶点。只要有可能，我们就会讨论使用一种模型而非其他模型来检验特定假设的优势。
总结
狼疮模型的自发性和诱导性模型是研究疾病病因、确定治疗靶点以及在临床前研究中筛选治疗方法的有用工具。每种模型都与人类观察到的疾病共享特定的属性子集，这为研究人员提供了一种根据其特定需求进行调整的工具。
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